摘要
针对生物医学工程对微/纳操作手的需求,提出了一种能够实现对微小细胞进行多重操作的微操作台。该平台由三自由度精密定位仪、负压驱动部件(V型直线超声电机、注射器和硅胶软管)和玻璃基纳米通孔构成。定位仪的定位精度为1μm,操作简便,定位效率高。利用负压驱动部件的V型直线超声电机产生吸附力,可以精确地吸附并控制特定的生物细胞。玻璃基纳米通孔的外径小于50μm,可以操作更微小的生物细胞。该操作台首次采用自主设计制造的V型直线超声电机和玻璃基纳米通孔作为关键部件。生物细胞操作实验表明,此操作台最终实现了对生物细胞的定位、吸附、释放和移动等操作,所操作的细胞大小在20μm以内。
For the demand of micro/nano manipulator in the biomedical engineering,a kind of micro-operation platform which can perform multiple operations on the biological tiny cells is proposed in this paper.The platform is consists of a 3-DOF precision positioning instrument,negative pressure drive unit(the V type linear ultrasonic motor,syringe and silicone hose)and the nanometer through hole based on glass.The accuracy of the positioning instrument is 1μm,the instrument is easy to operate and has high positioning efficiency.The specific biological cells can be adsorbed and controlled precisely by the absorption force which is generated in the negative pressure drive unit.The external diameter of the nanometer through hole is less than 50μm which can operate on more tiny biological cells.The independently designed and manufactured V type linear ultrasonic motor and the nanometer through hole are used as the key components in the platform for the first time.The experiments on the biological cell manipulation show that the positioning,adsorption,release and movement of biological cells are carried out finally in the operation platform.The size of the operated cells is less than 20μm.
出处
《压电与声光》
CAS
CSCD
北大核心
2017年第1期19-22,共4页
Piezoelectrics & Acoustooptics
基金
国家自然科学基金资助项目(51275229)
国家重大仪器设备开发专项基金资助项目(2012YQ100225)
关键词
微纳操作
直线超声电机
纳米通孔
生物技术
细胞
micro/nano operation
linear ultrasonic motor
nanometer through hole
biological technology
cells
