摘要
目的研究二甲双胍用于2型糖尿病患者治疗中的效果。方法 200例2型糖尿病患者,根据治疗方法的不同分为对照组和观察组,各100例。对照组患者采用格列齐特治疗,观察组患者给予格列齐特联合二甲双胍治疗。比较两组患者的血脂、血糖、胰岛素等指标水平。结果治疗8周后,观察组患者空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于对照组,差异具有统计学意义(P<0.05);观察组患者总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平低于对照组,高密度脂蛋白胆固醇(HDL-C)水平高于对照组,差异具有统计学意义(P<0.05)。观察组患者空腹胰岛素为(9.2±1.5)mU/L、餐后2 h胰岛素为(21.8±2.6)mU/L、稳态胰岛素指数为(4.3±0.6),均低于对照组的(11.4±1.8)mU/L、(27.5±3.1)mU/L、(8.5±1.2),差异具有统计学意义(P<0.05)。结论二甲双胍用于2型糖尿病患者中有助于平稳患者的血糖水平,调节血脂水平和胰岛素情况,提高患者的生活质量,值得推广应用。
Objective To research effect by metformin applied in treating type 2 diabetes mellitus patients. Methods A total of 200 patients with type 2 diabetes mellitus were divided by different treatment measures into control group and observation group, with 100 cases in each group. The control group received gliclazide for treatment, and the observation group received gliclazide combined with metformin for treatment. Comparison was made on indexes levels, such as blood lipid, blood glucose and insulin, between the two groups. Results After 8-week treatment, the observation group had all lower fasting blood glucose, 2 h postprandial blood glucose, and glycosylated hemoglobin levels than the control group, and the difference had statistical significance（P〈0.05）. The observation group had lower total cholesterol（TC）, triglyceride（TG）, low density lipoprotein cholesterin（LDL-C）, and higher high density lipoprotein cholesterin（HDL-C） levels than the control group, and their difference had statistical significance（P〈0.05）. The observation group had all lower fasting insulin as（9.2±1.5） mU/L, 2 h postprandial insulin as（21.8±2.6） mU/L, and steady-state insulin index as（4.3±0.6） than（11.4±1.8） mU/L,（27.5±3.1） mU/L and（8.5±1.2） in the control group, and their difference had statistical significance（P〈0.05）. Conclusion Implement of metformin in type 2 diabetes mellitus patients is helpful to stabilize blood glucose level, regulate blood lipid and insulin condition, and improve quality of life in patients. This method is worth promoting and applying.
出处
《中国实用医药》
2016年第34期10-12,共3页
China Practical Medicine
关键词
二甲双胍
2型糖尿病
格列齐特
血脂
血糖
胰岛素
Metformin
Type 2 diabetes mellitus
Gliclazide
Blood lipid
Blood glucose
Insulin
