摘要
目的探讨乌司他丁联合小剂量糖皮质激素在慢性鼻窦炎患者临床治疗中的应用效果及对患者机体内炎症因子表达水平的影响。方法将84例慢性鼻窦炎患者随机分为试验组和一般组,于围术期给予一般组患者小剂量糖皮质激素治疗,予以试验组患者乌司他丁联合小剂量糖皮质激素治疗。结果术前两组患者的炎症因子表达水平比较无明显差异(P>0.05),术后1周试验组患者的炎症因子表达水平较一般组患者低(P<0.05),治疗总有效率较一般组患者高(92.9%VS76.2%;P<0.05)。结论乌司他丁联合小剂量糖皮质激素在慢性鼻窦炎患者临床治疗中的应用,能够有效减轻患者术后的炎症反应,改善患者临床治疗效果,利于患者病情早日康复。
Objective To investigate the clinical application effect of ulinastatin combined with low-dose corticosteroids in the treatment of patients with chronic sinusitis and its affect on the expression of inflammatory factors.Methods 84 cases of patients with chronic sinusitis were randomly divided into the combined group and the general group. Patients in the general group received small doses of glucocorticoid for treatment,patients in the test group received ulinastatin combined with low-dose glucocorticoid for treatment.Results The preoperative inflammatory cytokine expression levels of the two groups with no significantly difference（ P〉0. 05）. One week after the surgery,the expression of inflammatory cytokines in the combined group was lower than that in the general group（ P〈0.05）. However,the total effective rate in combined group was higher than that in the general group（ 92. 9% VS76. 2%; P〈0. 05）. Conclusions UTI combined with low dose glucocorticoid in the clinical treatment of chronic sinusitis patients, can effectively reduce postoperative inflammation, improve clinical treatment effect of patients,it is conducive to a speedy recovery.
出处
《齐齐哈尔医学院学报》
2016年第31期3885-3886,共2页
Journal of Qiqihar Medical University
