摘要
最近研究发现,在B细胞滤泡周围发现一类新的CD8^+T细胞亚群即CXCR5^+CD8^+T细胞亚群,也称为滤泡细胞毒性T细胞(follicular cytotoxic T cells,TFC)亚群,该亚群引起了人们广泛的兴趣。到目前为止,TFC参与生发中心免疫反应的一些过程和机制及其作用还不完全明确。本文综述了国内外研究中TFC的表型、生理功能、成熟与分化的调节因素及其在HIV感染中的作用与临床意义。TFC功能表现出强大的应用前景,我们相信对其进一步研究有可能开启控制或治愈慢性病毒感染或肿瘤的另一种重要的细胞治疗方式。
Recent studies have shown that a new subset of CD8^＋ T cells named as CXCR5^＋ CD8^＋ T cells has been found around B cell follicles. This subset is also known as follicular cytotoxic T cells（TFC）, and has aroused widespread interests. So far, some of the processes and mechanisms of TFC＇s involvement in the germinal center immune response and its role within it are not fully understood. In this article, we summarized results of all domestic and foreign studies on the phenotypes, physiological functions, and moderating factors of maturation and differentiation of TFC, as well as their roles and clinical significance in the HIV infection. The function of TFC cells has shown a broader application prospects, and we believe that the further research on TFC may find another important cell therapy on the control or cure of chronic viral infection or tumor.
出处
《传染病信息》
2016年第6期321-323,344,共4页
Infectious Disease Information
基金
国家自然科学基金项目(81371803)
北京市自然科学基金项目(7152072)
关键词
滤泡细胞毒性T细胞
HIV感染
进展
follicular cytotoxic T cells
HIV infection
research progress
