摘要
目的探讨微创血肿碎吸引流术联合尼莫地平对高血压性脑出血患者的疗效。方法将2012年9月～2016年2月在我院神经内科治疗的60例高血压性脑出血患者随机分为两组，对照组采用微创血肿碎吸引流术加常规治疗方法，观察组在此基础上使用尼莫地平治疗，比较两组患者的治疗效果、神经功能、血肿及水肿情况及神经元特异性指标变化。结果观察组治疗有效率为93．33％，显著高于对照组的83．33％，差异有统计学意义（P〈0．05）；观察组治疗后NIHSS及SSS评分明显优于对照组，差异有统计学意义（P〈0．05）；观察组治疗后血肿及水肿量明显较对照组减小，差异有统计学意义（P〈0．05）；观察组治疗后神经元特异性烯醇化酶（NSE）和铁蛋白（SF）与对照组相比差异有统计学意义（P〈0．05）。结论微创血肿碎吸引流术联合尼莫地平对高血压性脑出血疗效确切，能有效减少脑血肿及水肿，改善局部脑组织周围血功能，促进神经功能的恢复，具有积极的临床意义。
Objective To explore the curative effect of minimally invasive hematoma suction flow combined with nimodipine to hypertensive cerebral hemorrhage patients. Methods 60 cases of hypertensive cerebral hemorrhage patients cured in department of neurosurgery of our hospital from Septembr 2012 to February 2016 were randomly divided into two groups. Patients in control group were treated with minimally invasive hematoma suction flow combined with conventional therapy method, and patients in observation group were treated with nimodipine therapy meth on the basis of control group. Treatment effect, nerve function, hematoma and edema, and the changes of neuron specific index of the two groups were compared. Results The effective rate of observation group was 93.33%, which was significantly higher than that of the control group with 83.33%, and the difference had statistical significance （P 〈 0.05）. The SSS and NIHSS scores of observation group after treatment were significantly better than those of control group, and the differences were statistically significant （P 〈 0.05）. The amount of hematoma and edema after treatment of observation group was significantly lower than those of control group, and the differences were statistically significant （P 〈 0.05）. There were significant differences in the neuron specific （NSE） and ferritin （SF） after treatmentbetween observation group and control group （P 〈 0.05）. Conclusion Curative effect of minimally invasive hematoma suction flow combined with nimodipine in treatment of hypertensive cerebral hemorrhage is definite. It can effectively reduce the cerebral hematoma and edema, improve local blood function around the brain tissue, and promote the recovery of neurological function. It has a positive clinical significance.
出处
《中国医药科学》
2016年第20期163-166,共4页
China Medicine And Pharmacy
关键词
高血压性脑出血
微创血肿碎吸引流术
尼莫地平
疗效观察
Hypertensive cerebral hemorrhage
Minimally invasive hematoma suction flow
Nimodipine
Curativeeffect observation
