摘要
目的:探讨瑞舒伐他汀对糖尿病高胆固醇血症患者血糖、血脂、炎症因子及肝功能的影响。方法:选取我院糖尿病高胆固醇血症患者108例,随机分为治疗组及对照组,各54例;治疗组采用瑞舒伐他汀治疗,对照组采用阿托伐他汀治疗,两组均连续治疗8周,检测并比较两组血糖、血脂、炎症因子水平和肝功能变化。结果:治疗后两组空腹葡萄糖(FBG)、餐后2h葡萄糖(PBG)、C反应蛋白(CRP)和白细胞介素-6(IL-6)水平显著低于治疗前(P<0.05),且治疗组显著低于对照组(P<0.05);治疗后两组总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)水平显著低于治疗前,高密度脂蛋白胆固醇(HDL-C)水平显著高于治疗前(P<0.05),且TC和LDL-C水平组间差异显著(P<0.05);治疗前后两组谷草转氨酶(AST)、谷丙转氨酶(ALT)、肌酸激酶(CK)水平比较差异无统计学意义(P>0.05)。结论:糖尿病高胆固醇血症患者采用瑞舒伐他汀进行治疗,能够有效降低机体血糖、血脂水平,改善机体炎症因子水平,效果显著,值得临床推广应用。
Objective：To explore the effect of rosuvastatin on the blood glucose,blood lipid,inflammatory cytokines,and liver function in patients with diabetes and hypercholesteremia.Methods：A total of 108 patients with diabetes and hypercholesteremia who were admitted in our hospital were included in the study and randomized into the treatment group and the control group with 54 cases in each group.The patients in the treatment group were given rosuvastatin,while the patients in the control group were given atorvastatin.The patients in the two groups were continuously treated for 8weeks.The blood glucose,blood lipid,inflammatory cytokines,and liver function in the two groups were detected and compared.Results：FBG,PBG,CRP,and IL-6levels after treatment in the two groups were significantly reduced when compared with before treatment（P〈0.05）,and those in the treatment group were significantly lower than those in the control group（P〈0.05）.TC,TG,and LDL-C levels after treatment in the two groups were significantly reduced when compared with before treatment（P〈0.05）,while HDL-C level was significantly elevated when compared with before treatment（P〈0.05）.The comparison of TC andLDL-C levels between the two groups was not statistically significant（P〈0.05）.The comparison of AST,ALT,and CK levels before and after treatment between the two groups was not statistically significant（P〈0.05）.Conclusions：Rosuvastatin in the treatment of diabetes and hypercholesteremia can effectively reduce the blood glucose and blood lipid levels,and improve the inflammatory cytokines,with a significant effect;therefore,it deserves to be widely recommended in the clinic.
作者
夏杰
蔡春天
XIA Jie CAI Chun-tian(Department gangjiaping General Medicine, Traditional Chinese Medicine Hospital of Jiulongpo District, Chongqing 400050, China Traditional Chinese Medicine Hospital of J iulongpo District, Chongqing 400080, China)
出处
《海南医学院学报》
CAS
2017年第4期501-503,共3页
Journal of Hainan Medical University
基金
重庆市科技支撑项目(201605131235)~~
关键词
瑞舒伐他汀
糖尿病高胆固醇血症
血糖
血脂
炎症因子
Rosuvastatin
Diabetes and hypercholesteremia
Blood glucose
Blood lipid
Inflammatory cytokine
