摘要
采用溶胶-凝胶法,以三乙醇胺为碱性沉淀剂,十六烷基三甲基溴化铵(CTAB)为模板剂,正硅酸乙酯(TEOS)为硅源,制备了介孔结构介孔二氧化硅纳米粒子(MSNs)。以硅烷偶联剂3-(异丁烯酰氧)丙基三甲氧基硅烷(MPS)对介孔二氧化硅进行表面修饰,以甲基丙烯酸(MAA)为原料,采用原位聚合法制备了具有pH响应性的介孔二氧化硅纳米粒子@聚甲基丙烯酸(MSNs@PMAA)复合微球。利用小角X射线粉末衍射仪、扫描电子显微镜和透射电子显微镜等仪器对其结构和形貌进行了表征。研究结果表明:MSNs@PMAA复合微球平均直径为167 nm,具有长程有序介孔孔道,MSNs的比表面积、孔容和孔径分别从1 081 m^2/g、1.756cm^3/g和3.2 nm减小至506 m^2/g、1.340 cm^3/g和1.7 nm。以多柔比星(DOX)为模型药物,MSNs@PMAA复合微球显示了较高的载药率和包封率,在体外有明显的p H响应性。
Mesoporous silica nanoparticles( MSNs) were synthesized by sol-gel method with triethanolamine as mild alkaline catalyst,cetyl trimethyl ammonium bromide( CTAB) as template,TEOS as silicon source. The mesoporous silica surface was modificed with a silane coupling agent 3-( methacryloxy) propyl trimethoxysilane( MPS). Mesoporous silica nanoparticles-polymethylacrylic acid( MSNs@ PMAA) composite microspheres were synthesized by precipitation polymerization method with methacrylic acid( MAA) as raw material,which exhibited obvious p H responsiveness. The structure and morphology of MSNs@ PMAA composite microspheres were characterized by small-angle X-ray powder diffraction,Fourier-transform infrared spectroscopy,transmission electron microscopy,and other characterization methods. The results show that MSNs @ PMAA composite microspheres possess long-range mesoporous channel,and their average diameter are 167 nm. The specific surface area,pore volume and pore size of MSNs are reduced from 1 081 m^2/ g,1. 756 cm^3/ g,3. 2 nm to 506 m^2/ g,1. 340 cm^3/ g,1. 7 nm,respectively. By using doxorubicin( DOX) as a model drug,MSNs @PMAA composite microspheres show higher drug loading rate,encapsulation efficiency and obvious p H responsiveness in vitro.
出处
《河南科技大学学报（自然科学版）》
CAS
北大核心
2017年第2期99-104,共6页
Journal of Henan University of Science And Technology:Natural Science
基金
国家自然科学基金项目(51375142)
河南省科技厅科技攻关基金项目(142102210393)
河南大学大学生创新创业支持计划基金项目(MSCXCY2015054)
关键词
介孔二氧化硅纳米粒子
溶胶-凝胶法
环境响应性
药物控释
mesoporous silica nanoparticle
sol-gel technology
environmental responsiveness
controlled drug release
