摘要
目的观察半夏厚朴汤加减治疗难治性胃食管反流病的疗效并探讨其机制。方法选择符合诊断标准的80例患者通过随机分配方案隐匿的方法(按顺序编码、不透光、密封的信封)分为实验组和对照组,对照组给予雷贝拉唑及莫沙必利治疗,实验组在上述西药基础上配合半夏厚朴汤加减煎服,观察8周,治疗前后分别进行胃食管反流病诊断问卷症状积分(Gerd Q),评分及高分辨率食管测压检查。结果治疗后实验组Gerd Q积分与对照组相比有明显改善,实验组总有效率为94.74%,对照组总有效率为77.14%,且实验组食管食管下括约肌静息压力治疗后(15.01±7.79 mmHg)较治疗前(14.35±7.83 mmHg)有明显升高,差异均有统计学意义(P<0.05)。结论半夏厚朴汤治疗难治性胃食管反流病临床疗效显著,可改善食管食管下括约肌静息压力。
Objective To observe the clinical effect and mechanisms of Banxia Houpu decoction for refractory gastroesophageal reflux disease（rGERD）. Methods A total of 80 patients were randomly divided into two groups. The control group was given rabeprazole and mosapride. The experimental group was administered with Pinelliae and Magnoliae Officinalis Decoction besides the western medicine. Gerd Q and high resolution manometry were performed before and after 8 week treatment. Results After treatment, the Gerd Q score of the experimental group was significantly improved compared with the control group. The total effective rate of experimental group was 94.74% while the control group was 77.14%. And the resting pressure of esophageal LES（15.01 ± 7.79 mmHg） was significantly higher than that before treatment（14.35 ± 7.83 mmHg） in the experimental group. The difference was statistically significant（P〈0.05）. Conclusion Banxia Houpu decoction has significant effect in treatment of rGERD. It can improve the resting pressure of the esophageal LES.
作者
余丹纯
贾林
余永森
刘静
黄耀星
Yu Danchun JIA Lin YU Yongsen LIU Jing HUANG Yaoxing(Department of GI Medicine Department of Traditional Chinese Medicine,The First People＇s Hospital of Guangzhou,Guangzhou 510180,China)
出处
《分子影像学杂志》
2017年第1期48-50,共3页
Journal of Molecular Imaging
基金
广州市中医药和中西医结合科技项目(20162A01001)
关键词
半夏厚朴汤
难治性胃食管反流病
高分辨率测压
Banxia Houpu decoction
refractory gastroesophageal reflux disease
high resolution manometry
