摘要
目的探讨尿液白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α在糖尿病肾病中的改变及其意义。方法选择2型糖尿病患者168例纳入研究组,按照尿清蛋白/肌酐(UACR)分为正常蛋白尿、微量蛋白尿组、大量蛋白尿组3组,另将53例健康体检者纳入对照组,所有受试者常规检测临床生化指标(空腹血糖、糖化血红蛋白、尿蛋白等),以及尿液IL-6、TNF-α浓度,分析这些指标在各组间的差异。结果 2型糖尿病患者尿液IL-6、TNF-α浓度均高于对照组,并随UACR升高,在3组中依次升高;尿液TNF-α不仅与UACR呈正相关,也是2型糖尿病患者出现蛋白尿的独立危险因素[OR=3.245,95%置信区间(CI)为1.432~5.532]。结论尿液TNF-α可反映糖尿病患者肾脏损伤程度,具有早期诊断DN的应用前景。
Objective To learn the clinic vale of urinary interleukin（IL）-6and tumor necrosis factor（TNF）-αin patients with diabetic nephropathy（DN）.Methods A total of 168 cases with type 2diabetes mellitus were recruited into study group,and patients were further categorized into normal-albuminuria group,micro-albuminuria group,and macro-albuminuria group according to their urine albumin/creatinine ratio（UACR）.Other 53 healthy persons were entered into control group.The data of fasting glucose,glycosylated hemoglobin,urine protein,and urinary IL-6,TNF-αwere analyzed.Results Compared with the control group,urinary IL-6and TNF-αin type 2diabetes mellitus patients were all markedly increased.Urinary TNF-αwas positively correlated with UACR,and was independent risk factor of proteinuria[OR=3.245,95%CI was 1.432-5.532].Conclusion Urinary TNF-αwas related with the renal injury in type 2diabetes mellitus,and might be a early marker of DN.
出处
《检验医学与临床》
CAS
2017年第3期348-349,共2页
Laboratory Medicine and Clinic
