摘要
肠道菌群组成、特异性菌种或菌群的变化与各类疾病的发生有密切的相关性.本文系统阐述了肠道菌群失调与高血压、动脉粥样硬化、心肌梗塞和心力衰竭等心血管疾病的相关性,肠道菌群的种类变化和可能的致病机制,肠道菌群失调可能是促进心血管疾病发生的原因之一.调控肠道菌群有望作为心血管疾病的潜在治疗新靶点,如应用抗生素降低血压、益生菌调节高脂血症和降压;采用干扰肠道菌群代谢活性的药物,如降低氧化三甲胺水平来防治心血管疾病,通过地中海式饮食来预防心血管疾病.
It has been demonstrated that gut microbiota,such as microbiota component,specific flora,and category changes,is highly associated with different diseases.This review systematically describes the association between the dysbiosis of gut microbiota and specific cardiovascular diseases,e.g.,hypertension,atherosclerosis,myocardial infarction,and heart failure.In addition,we discuss the category changes in gut microbiota found in these diseases and the possible pathogenic mechanisms.Gut dysbiosis may be one of the causes of cardiovascular diseases.Antibiotics and probiotics have a positive effect on blood pressure,and probiotics also work in hyperlipemia.Drugs altering the metabolic activity of gut microbiota can decrease the level of trimethylamine N-oxide and thus lower blood pressure.In addition,it has been found that the Mediterraneanstyle diet can prevent cardiovascular diseases.Therefore,regulation of gut microbiota might be a potential therapy for cardiovascular diseases.
出处
《世界华人消化杂志》
CAS
2017年第1期31-42,共12页
World Chinese Journal of Digestology
基金
广东省高水平大学重点学科建设"感染性疾病研究与防治"项目子课题基金资助项目
No.2015048~~
关键词
肠道菌群
高血压
动脉粥样硬化
心肌梗塞
氧化三甲胺
心力衰竭
心血管疾病
相关性
抗生素
益生菌
Gut microbiota
Hypertension
Atherosclerosis
Trimethylamine N-oxide
Myocardial infarction
Heart failure
Cardiovascular disease
Association
Antibiotics
Probiotics
