摘要
CaBP-9k和CaBP-28k是一类具有维生素D依赖性的钙结合蛋白，在钙离子的主动转运过程中发挥着重要作用。研究表明维生素D能够上调机体钙离子结合蛋白的表达含量，从而促进机体对钙离子的吸收。维生素D和钙结合蛋白的缺乏可以导致机体钙稳态的失调，出现低钙血症、佝偻病、骨质疏松等病变。该文对钙结合蛋白的结构、在机体的分布、受维生素D调控的机制等研究进展作一综述，以期为预防和治疗骨发育异常提供新思路。
Calbindin 9K（CaBP-9k） and Calbindin 28K（ CaBP-28k）, vitamin D dependent calcium binding protein（CaBP） ,play an important role in the the process of active transport of calcium. Research has shown that vitamin D can increase the expression of calcium binding protein, which can promote the absorption of calcium ions. Vitamin D deficiency and calcium binding protein could cause disorders of calcium homeostasis, such as hypocalcemia, rickets, osteoporosis and many other diseases. This review summarizes the studies of structure and distribution of CaBP and the mechanism of vitamin D in regulation of CaBP, which might provide new strategies for the prevention and treatment of paraplasia ossium.
作者
董亚萍
杨丽萍
罗文婷
赵群
Dong Yaping Yang Liping Luo Wen- ring Zhao Qun(Key Laboratory of Congenital Malformation,Ministry of Health, Pediatric Orthopaedics Department, Shengjing Hospital of China Medical University, Shenyang 110004, China)
出处
《国际儿科学杂志》
2017年第1期59-63,共5页
International Journal of Pediatrics
基金
国家自然科学基金（81572095,81271938）
辽宁省科技计划资助项目（2013225079）
