摘要
目的:评价复方苦参注射液联合化疗治疗晚期大肠癌的疗效与安全性。方法:采用计算机检索Cochrane Central、Pub Med、Embase、中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、维普中文科技期刊全文数据库(VIP)、万方数据库文献,筛选复方苦参注射液联合化疗治疗晚期大肠癌的随机对照试验,评价纳入研究的质量,提取资料,用Rev Man 5.3软件进行Meta分析。结果:共纳入12项研究含894例患者。Meta分析结果:与单纯化疗组比较,联合治疗组能提高患者近期有效率,改善生活质量,并降低骨髓抑制、胃肠道反应、肝功能损伤及神经毒性反应,差异均有统计学意义(P<0.05),但未降低血小板减少发生率(P>0.05)。结论:复方苦参注射液联合化疗可提高晚期大肠癌的近期有效率,改善生活质量并降低化疗毒副作用,但纳入研究质量不高,结论需要更多高质量、大样本的RCT进一步验证。
Objective： To evaluate the effectiveness and safety of Compound Kushen Injection （复方苦参注射液） combined with chemotherapy for advanced colerectal cancer. Methods： The seven databases as follows： Cochrane Central, PubMed, Embase, CNKI, VIP and WanFang, were retrieved by computer. Randomized con- trolled trials （RCTs） about Compound Kushen Injection combined with chemotherapy in the treatment of ad- vanced colorectal cancer were screened. Two reviewers in dependly evaluate the quality of inCIuded studies and extracted data, Meta-analysis was performed by using RevMan 5.3 software. Results： A total of 12 RCTs in- volving 894 participants were included. The results showed that compared to using chemotherapy alone, Com- pound Kushen Injection combined with chemotherapy increased effective rate, improved the quality of life, re- duced the incidence rate of hypolerkia, nausea and vomiting, diarrhea, hepatic function injury and neurotoxicity, there was statistical significance （P〈0.05）. There was no statistical significance in thrombocytopenia between two groups （P〉0.05）. Conclusion： Compound Kushen Injection Combined with Chemotherapy can improve the efficancy for advanced colorectal cancer patients and reduce side effects. However, considering about low quality of inCIuded studies, more high quality, large sample RCTs are stilled needed for confirmation.
出处
《中医药导报》
2017年第2期41-46,共6页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
北京市科技计划项目(No.161100005116005)
关键词
大肠癌
复方苦参注射液
化疗
META分析
随机对照试验
colorectal cancer
compound Kushen injection
chemotherapy
Meta-analysis
randomized controlled trials
