摘要
肝X受体是孤核受体超家族成员之一,其天然配体为氧化固醇,越来越多的证据表明,肝X受体可能对心脏具有直接的有益作用。心力衰竭是心血管疾病的终末表现,且随着老龄化的发展,发病率逐年增加。研究发现肝X受体在动脉粥样硬化、高血压、糖尿病、心肌肥厚、心肌纤维化等发展中起着重要作用,这使得肝X受体成为心力衰竭治疗的理想靶点。
Liver X receptors are members of the nuclear receptor superfamily,which their natural ligands are oxysterols. More and more studies suggest that liver X receptors may have a direct beneficial effect on the heart.Heart failure is the terminal progression of cardiovascular disease and its prevalence is increasing in our aging society.Research has outlined the importance of liver X receptors signaling pathways in the development of atherosclerosis,hypertension,diabetes,cardiomyocyte hypertrophy and cardiac fibrosis. These observations make liver X receptors an attractive agent for therapeutic treatments of heart failure.
作者
蔡景景
富路
CAI Jingjing FU Lu(Department of Cardiology, Xingan League People＇s Hospital, Xingan league 137400, Inner Mongolia, China Department of Cardiology ,The First Affiliated Hospital of Harbin Medical University ,Harbin 150001 ,Heilongjiang, China)
出处
《心血管病学进展》
CAS
2017年第1期118-121,共4页
Advances in Cardiovascular Diseases
