摘要
目的了解辽宁省本溪市手足口病流行现状及病原学特征,及时掌握手足口病流行规律和趋势。方法对2012—2015年本溪市手足口病资料进行分析,采用逆转录PCR方法进行病毒核酸检测。结果 2012—2015年本溪市共报告手足口病病例2 276例,年均发病率为33.23/10万,无重症和死亡病例。病例高发期在6-9月份;发病年龄主要为1~5岁,病例以托幼儿童和散居儿童为主,男性高于女性。2012—2015年共检测1 105例手足口病标本,检出阳性标本659例,阳性检出率为59.64%。阳性标本中,CoxA16型、EV71型、CoxA16型和EV71型混合感染及其他肠道病毒的构成比分别为28.83%、21.40%、2.73%和47.04%,病原构成呈动态变化。结论2012—2015年本溪市手足口病发病存在明显的时间、地区、年龄、性别和职业差异,发生的手足口病主要由CoxA16和EV71型病毒引起,是EV71型和CoxA16型为主混合型感染地区,目前逐渐向以其他肠道病毒为主混合型感染地区转变。
Objective To describe epidemic status and etiological characteristics of hand foot and month disease （HFMD） in Benxi municipality of Liaoning province and to explore epidemic pattern and trend of HFMD. Methods Data on reported HFMD cases in Benxi city from 2012 to 2015 were statistically analyzed and reverse transcription PCR （RT-PCR） method was used to detect viral nucleic acid in specimens collected from the cases. Results A total of 2 276 HFMD cases were reported in Benxi city during the 4-year period, with an average annual incidence rate of 33.23/ 100 000, and no severe or death case were reported. More cases were reported between June and September in a year. Of the reported cases,82.21% were aged 1 -5 years; 56. 15% and 37,21% were children living scattered and in nurseries or kindergartens. The male to female ratio was 1.61 ： 1 for all the reported cases. For a total of 1 105 specimens detected during the period,659 were positive to viral nucleic acid and the positive rate was 59. 64%. For all the positive specimens the detection ratios were 28. 83 % for coxsackievirus A16 （CoxA16） ,21.40 % for enteroviruses 71 （ EV71 ） ,2. 73 % for both CoxA16 and EV71, and 47. 04 % for other enteroviruses, respectively. A dynamic changes in the pathogen distribution was observed among the reported cases. Conclusion The incidence of HFMD differed by time,region,age,sex,and other demography variables and major pathogens of the epidemics were CoxA16 and EV71, with a change from the dominant prevalence of CoxA16 and EV71 to other enterovirus dominant prevalence,in Benxi city between 2012 and 2015.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2017年第2期321-324,共4页
Chinese Journal of Public Health
关键词
手足口病
流行病学
病原学
hand-foot-mouth disease
epidemiology
etiology
