摘要
目的探讨抗酿酒酵母抗体(ASCA),抗胰腺腺泡抗体(PAB),抗小肠杯状细胞抗体(GAB),抗中性粒细胞胞浆抗体(ANCA)对炎症性肠病(IBD)的诊断以及溃疡性结肠炎(UC)和克罗恩病(CD)鉴别诊断的临床意义。方法收集200例临床检测IBD抗体谱的患者血清,采用间接免疫荧光法(IF)测定。结果 200例患者血清中,106例有阳性或弱阳性指标。其中,ASCA阳性/弱阳性24例,PAB阳性/弱阳性14例,GAB阳性/弱阳性63例,ANCA阳性/弱阳性28例,并分别纳入ASCA组,PAB组,GAB组,ANCA组。ANCA和GAB诊断UC的阳性率分别为34%和58%。ASCA和PAB诊断CD的阳性率分别为28.6%和38.1%。ANCA与GAB联合检测诊断UC的特异度为60%,ASCA与PAB联合检测诊断CD的特异度为75%。结论 IBD抗体谱里ASCA,ANCA,GBA和PAB四种抗体的联合检测对IBD的诊断有重要指导价值,也可作为UC与CD的鉴别诊断方法之一。
Objective To investigate clinical significance of diagnosis of the anti saccharomyces cerevisiae antibody （ASCA）, pancreatic aeini antibody （PAB） resistance, resistance to small goblet cell antibody （GAB）,anti neutrophil cytoplasm anti- bodies （ANCA） for inflammatory bowel disease （IBD） and the differential diagnosis of ulcerative colitis （UC） and crohn＇s disease （CD）. Methods Collected 200 cases of test group sets of inflammatory bowel disease,serum by indirect immunofluo- rescence （IF）. Results In the serum of 200 patients,106 cases with positive or weakly positive. Among them,the positive ASCA/weak positive 24 cases, 14 cases of PAP,, GAB 63 cases, 28 cases ANCA, and included in ASCA group respectively and PAP, group,GAp＂ group,ANCA group. Positive rate of ANCA and GAP, in the diagnosis of UC were 34% and 58%. Positive rate of ASCA and PAP, in the diagnosis of CD were 28.6% and 38.1%. ANCA associated with GAP, detection in the diagnosis of UC specific degree was 60%, ASCA associated with PAB detection in the diagnosis of CD specific degree was 75 %. Conclusion Serum inflammatory bowel disease antibody spectrum in ASCA, ANCA,GP＇A and PAP, four antibod- ies of joint detection has important guiding value to the diagnosis of IBD,also can be used as one of UC and CD in the differ- ential diagnosis methods.
出处
《现代检验医学杂志》
CAS
2017年第1期141-143,共3页
Journal of Modern Laboratory Medicine
关键词
炎症性肠病
抗酿酒酵母细胞抗体
抗中性粒细胞胞浆抗体
抗小肠杯状细胞抗体
抗胰腺腺泡抗体
inflammatory bowel disease（IBD）
anti saccharomyces cerevisiae antibody（ASCA）
anti neutrophil cytoplasm anti-bodies（ANCA）
small goblet cell antibodies（GAB）
pancreatic aeini antibody（PAB）
