摘要
细胞外信号调节激酶(Extracellular Signal-Regulated Kinases,ERK)包括两种异构体ERK1和ERK2,二者的同源性接近90%。分裂原活化抑制剂(MEK)位于Raf-MEK-ERK通路,分为MEK1和MEK2两种,通过使Tyr和Thr两个调节位点磷酸化而激活ERK。MEK/ERK通路可以调节多种细胞功能,与多种疾病的病理过程有密切的联系。支气管哮喘反复发作,缠绵难愈,是一种以慢性气道炎症为特征的异质性疾病。MEK/ERK通路对支气管哮喘发病的多个环节起到重要的调节作用。将从MEK/ERK通路的生物学特性、MEK/ERK通路与支气管哮喘发病机制的关系两方面予以阐述。
Extracellular Signal -Regulated Kinases （ERK） includes ERK1 and ERK2. The honology of the two was nearly 90%. MEK is a part of Raf - MEK - ERK pathway, which is divided into MEK1 and MEK2 and can activate ERK by phosphorylating Tyr and Thr. MEK/ERK pathway can regulate a variety of cellular functions and is closely linked with the pathology of many diseases. Bronchial asthma, recurrent and lingering refractory, is a kind of heterogeneous disease characterized by chronic airway inflammation. MEK/ERK pathway plays an important regulatory role in the pathogenesis of asthma. The article would expatiate the biological characteristics of MEK/ERK pathway and the relationship between MEK/ERK pathway and bronchial asthma pathogenesis.
出处
《中华中医药学刊》
CAS
北大核心
2017年第2期329-331,共3页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(81303046)
