摘要
目的:探讨Wnt/β-catenin信号通路相关蛋白Wnt1、β-catenin在硝苯地平引起的药物性增生的牙龈组织中的表达。方法:选择正常牙龈对照组、(未服药)高血压牙龈增生组、硝苯地平引起的药物性牙龈增生组各10例,用Western-Blot和RT-PCR检测牙龈组织中Wnt1、β-catenin的表达。结果:药物性牙龈增生组的牙龈组织中Wnt1、β-catenin蛋白及mRNA表达水平显著高于正常牙龈对照组(P<0.05)和高血压牙龈增生组(P<0.05)。结论:硝苯地平引起的药物性牙龈增生的牙龈组织中Wnt1、β-catenin表达水平增高,可能通过Wnt/β-catenin信号通路促进牙龈成纤维细胞的增殖导致牙龈纤维化。
Objective： To study the expression of Wnt/β-catenin signaling pathway related proteins Wntl and β-catenin protein in gingival tissues of the patients with drug-induced gingival overgrowth （DGO） caused by nifedipine. Methods： Wntl and β-catenin expression were tested with Western Blot and RT-PCR in gingival tissues of 10 cases of DGO induced by nifedipine, 10 cases of high blood pressure with gingival hyperplasia（without use of any medicine） and 10 cases of healthy control. Results： In the gingival tis- sues of DGO group the levels of Wntl and β-catenin protein and mRNA were significantly higher than those of the healthy control group （ P 〈 0.05 ） and the high blood pressure group （ P 〈 0.05 ）. Conclusion： The levels of Wntl and β- catenin are increased in nifedipine induced gingival hyperplasia. The gingival hyperplasia may be caused by the promotion of gingival fibroblast proliferation through Wnt/β-catenin signaling pathway.
作者
崔硕
王鹏
高秀秋
CUI Shuo WANG Peng GAO Xiuqiu.(21000, The Second Affiliated Hospital of Jinzhou Medical University, China)
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2017年第1期78-82,共5页
Journal of Practical Stomatology
基金
全民口腔研究生科研创新基金(编号:QM2014014)
