摘要
超声协同微泡对生物壁面的声孔效应在靶向药物治疗等医疗领域受到普遍关注。通过超声造影剂与生物壁面间的相互作用了解声孔效应发生的概率。为此构建了单个造影剂微泡对生物壁面产生声孔效应的概率模型,并利用微泡振荡时在生物壁面的声反射效应,分析壁面的声反射系数及其激励频率等对于声孔效应的影响。数值模拟表明:造影剂微泡振荡时的声孔效应在弹性壁面发生的概率大于刚性壁面;声孔效应发生概率随超声频率在经历两个峰值后而逐渐趋向于零。该模型在评估生物壁面细胞的损伤及利用超声微泡在药物/基因传输的应用可提供理论参考。
The sonoporation of ultrasound contrast agent near biological walls has received wide attention in medical fields such as targeted drug therapy. The goal of this study is to understand the probability of sonoporation generated by an ultrasound contrast agent （UCA） detached from the biological walls. A theoretical model for the single free UCA microbubble to calculate the probability of sonoporation was proposed. Based on sound reflection coefficient in biological walls in ultrasound field, the affect of sound reflection factor and driving frequency on sonoporation is described analytically. The result shows the probability of sonoporation generated by UCA microbubble oscillation near elastic wall is more than that of near rigid wall. The frequency of the ultrasonic field on sonoporation after two peaks gradually tends to zero. This model may evaluate further the damage of biological ceils, and provide reference for understanding drug/ gene delivery.
出处
《黑龙江科学》
2016年第24期18-21,56,共5页
Heilongjiang Science
基金
湖南省自然科学基金项目(13JJ3076)
湖南省教育厅重点项目(14A127)
南华大学研究生科技创新项目(2015XCX14)
关键词
超声造影剂
生物壁面
声孔效应概率
Ultrasound contrast agent （UCA）
Biological wall
Sonoporation probability
