摘要
探索真实世界复方苦参注射液联合用药特征,针对其治疗恶性肿瘤的临床联用中西药物药理作用关联规律进行分析,为临床合理用药、治法模式的探索及后续深入分析提供参考借鉴。对来自22家医院诊断为恶性肿瘤且使用复方苦参注射液治疗的44 588例患者电子医疗数据进行提取,基于关联规则Apriori算法对所记载的联用中西药物药理特征进行基于电子医疗数据的真实世界回顾分析。研究结果解析了复方苦参注射液与中西药物联合应用治疗恶性肿瘤的真实世界临床规律,为临床治疗思路的拓展提供了有益参考,并为复方苦参注射液的临床合理应用提供了借鉴。鉴于该研究结果不具有强关联性及因果关系推断性,相关结论有待进一步深入研究分析验证。
Fufang Kushen injection is used in real world clinical situations to treat different types of malignant tumors. The present study aimed to analyze the association rules of Fufang Kushen injection in combination with other traditional Chinese medicine（ TCM）or modern medications in treating malignant tumors based on the electrical medical records extracted from real-world hospital information system. This real world retrospective analysis was based on the clinicians ’ prescriptions regarding to such treatment by combined TCM and modern medications. Hospital information system data from 22 hospitals,including electrical medical records of 44 588 patients with malignant tumors and Fufang Kushen injection were included in this study,providing useful reference for the development of clinical treatment ideas,and providing reference for clinical rational use of Fufang Kushen injection. High correlation and causal relations were not present in this study,so further exploration and analysis were still needed for the conclusion.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2017年第2期378-384,共7页
China Journal of Chinese Materia Medica
基金
国家"重大新药创制"科技重大专项(2015ZX09501004-001-002)
北京市中医药科技发展专项(JJ2014-53)
中国中医科学院自主选题项目(PY1303)
关键词
复方苦参注射液
真实世界
恶性肿瘤
联合用药
关联规则
Fufang Kushen injection
real world
malignant tumor
drug combinations
association rules
