摘要
目的探讨Chr20上rs6047844、rs1160312和Chr2上rs9287638、rs7349332位点的单核苷酸多态性与湖北汉族雄激素性脱发易感性的关系。方法采用病例对照研究,应用Sanger双脱氧直接测序法对50例雄激素性脱发患者(病例组)和49例健康对照者(对照组)rs6047844、rs1160312、rs9287638和rs7349332位点的单核苷酸多态性进行基因分型,分析这4个位点单核苷酸多态性与湖北汉族雄激素性脱发易感性的关系。结果在显性模型、隐性模型和共显性模型下,2组rs6047844、rs1160312、rs9287638和rs7349332位点的基因型频率和等位基因频率比较差异均无统计学意义(P均>0.05)。结论 rs6047844、rs1160312、rs9287638和rs7349332位点的单核苷酸多态性与湖北汉族雄激素性脱发易感性无关。
Objective It is to investigate the relationship between the single nucleotide polymorphisms（ SNPs） of Chr20（ rs6047844,rs1160312） and Chr2（ rs9287638,rs7349332） with the susceptibility to androgenic alopecia（ AGA） in the Han population of Hubei province. Methods For the case-control studies,the SNPs of rs6047844,rs1160312,rs9287638,rs7349332 of 50 patients with AGA（ case group） and 49 healthy controls（ control group） were genotyped using Sanger double deoxidation direct sequencing. The relationship between SNPs at the four sites and susceptibility to AGA in the Han population of Hubei province. Results There was no significant difference in genotype frequency and allele frequency of rs6047844,rs1160312,rs9287638,rs7349332 between the case group and the control group in three different models（ in dominant model,in recessive model and in codominant model）（ all P〉0. 05） .Conclusion The SNPs at rs6047844,rs1160312,rs9287638,rs7349332 are not associated with the susceptibility to AGA in Han population of Hubei province.
出处
《现代中西医结合杂志》
CAS
2017年第6期574-576,607,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
湖北省自然科学基金资助项目(2014CFB470)
