摘要
以自制的生物可降解线性-树枝状两嵌段两亲共聚物材料为药物载体,采用透析法制备了雷帕霉素载药微球。通过扫描电子显微镜(SEM)、动态光散射仪(DLS)、紫外分光光度计对雷帕霉素载药微球的表面形貌、粒径分布、载药量及释放行为进行了研究。结果表明:载药微球的载药量和包封率分别可达到40%和90%以上,与哑铃型三嵌段两亲共聚物载药微球相当,但平均粒径大幅降低(粒径约300nm),同样具有显著的缓释作用。
The rapamycin-loaded spherical microparticle based on biodegradable linear-dendritic diblock copolymer is prepared by dialysis method. Scanning electronic microscope（SEM） , dynamic light scattering （DLS） and UV spectrophotometer were used to investigate morphology, size and in vitro release behavior of these particles. The results showed that the drug content and encapsulation efficiency of drug-loaded microparticles prepared by diblock copolymer, as well as those prepared by dumbbell-shaped triblock copolymer, could be more than 40% and 90%, respectively. Meanwhile, the mean size of those microparticles reduced significantly and it showed an obvious sustained release as well.
出处
《华东理工大学学报（自然科学版）》
CAS
CSCD
北大核心
2017年第1期50-55,共6页
Journal of East China University of Science and Technology
关键词
线性-树枝状共聚物
生物可降解
载药微球
体外释放
雷帕霉素
linear-dendritic diblock copolymer
biodegradable
drug-loaded microparticles
drug in vitro release
rapamycin
