摘要
目的 分析HBeAg阳性及HBeAg阴性乙型肝炎病毒相关原发性肝癌患者生物化学指标及病毒载量。方法 随机选择2010年1月至2015年1月于本院住院的乙型肝炎病毒相关原发性肝癌患者200例,分析HBeAg阳性（137例）和HBeAg阴性（63例）患者的血常规、生物化学指标、甲胎蛋白（AFP）及HBV DNA载量等。结果 HBeAg阳性组患者的ALT与HBV DNA均高于与HBeAg阴性组,AFP水平低于HBeAg阴性组,差异有统计学意义（t值分别为0.011、4.090和0.137,P值分别为0.042、0.045和0.013）。两组患者中不同HBV DNA载量患者的比例差异有统计学意义（χ~2=9.582,P=0.007）。结论 HBV DNA病毒载量与ALT水平呈正相关。HBeAg阴性乙型肝炎病毒相关原发性肝癌发生率高于HBeAg阳性,且肝脏炎症程度重,甲胎蛋白水平更高,值得临床关注。
Objective To explore the biochemical markers and HBV DNA levels in hepatitis B virus-related primary liver cancer patients with HBeAg positive and HBeAg negative. Methods Total of 200 cases with hepatitis B virus-related primary liver cancer from January 2010 to January 2015 in our hospital were randomly selected. The blood routine, biochemical markers, alpha fetal protein （AFP） and HBV DNA levels were analyzed in patients with HBeAg positive （137 cases） and HBeAg negative （63 cases）. Results The levels of ALT and HBV DNA in HBeAg positive group were higher and AFP were lower than those in HBeAg negative group, the differences were statistically significant （t = 0.011, 4.090, 0.137; P = 0.042, 0.045, 0.013）. The ratio of patients with different HBV DNA level had statistical difference between two groups （3（2 = 9.582, P = 0.007）. Conclusion HBV DNA viral load was positively correlated with ALT level. The incidence of hepatitis B virus-related primary liver cancer in patients with HBeAg negative was higher than that of HBeAg positive, and the degree of liver inflammation and AFP were also higher.
出处
《中国肝脏病杂志（电子版）》
CAS
2016年第4期87-90,共4页
Chinese Journal of Liver Diseases：Electronic Version
基金
内蒙古科技厅计划项目(kjt12sf032)
