贝那普利联合阿托伐他汀治疗早期糖尿病肾病的临床分析被引量：2

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摘要目的探讨贝那普利联合阿托伐他汀治疗早期糖尿病肾病的临床效果。方法将早期糖尿病肾病患者70例分为对照组与观察组。对照组行贝那普利治疗,观察组加用阿托伐他汀治疗。结果观察组患者治疗有效率为88.57%,高于对照组患者的71.43%;观察组患者不良反应发生率为8.57%,低于对照组的25.71%(P<0.05);治疗前两组患者UAER(尿蛋白排泄率)、ACR(尿白蛋白/肌酐比值)、Hb A1c(血清糖化血红蛋白)、CRP(C反应蛋白)对比无明显差异(P>0.05),治疗后观察组患者UAER、ACR、Hb A1c、CRP改善情况明显优于对照组(P<0.05)。结论贝那普利联合阿托伐他汀治疗早期糖尿病肾病的效果显著。

作者朴成梅赵书平袁景

机构地区吉林省通化市中心医院肾内科

出处《中国医药指南》 2017年第3期116-117,共2页 Guide of China Medicine

关键词贝那普利阿托伐他汀早期糖尿病肾病

分类号 R587.2 [医药卫生—内分泌]

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1陈小盼,朱洪,宋钦华,郑海龙,孙胜花,李国铨.贝那普利对2型糖尿病肾病血清抵抗素水平的影响[J].现代预防医学,2011,38(12):2392-2393. 被引量：9
2王俊.贝那普利联合阿托伐他汀治疗早期糖尿病肾病疗效观察[J].中国现代医生,2011,49(8):63-64. 被引量：9
3王强,邓晓风,周莹.盐酸贝那普利辅助治疗早期糖尿病肾病56例疗效观察[J].中国医药指南,2014,12(4):38-39. 被引量：8
4万欢,沈小波,任汉强,王芳,马铭,陈伟.氯沙坦联合贝那普利治疗2型糖尿病肾病疗效观察[J].中国医学创新,2010,7(18):70-72. 被引量：7
5刘俊伏,赵勇军,李军伟,张刚.早期糖尿病肾病预防及治疗研究进展[J].医学研究与教育,2010,27(2):83-85. 被引量：62
6尹洪涛,潘兹海,陈秋.同型半胱氨酸和尿微量蛋白与2型糖尿病患者肾损害程度的关系[J].河南医学研究,2014,23(10):26-27. 被引量：4

二级参考文献49

1王先梅,杨丽霞,宋武战,齐峰,郭传明,石燕昆,赵颖,魏玲,王燕.盐酸贝那普利对自发性高血压大鼠肾脏纤维化的影响[J].第四军医大学学报,2006,27(20):1859-1862. 被引量：7
2Evans J L,Goldfine D,Maddux B A,et al.Oxidative stress and stress actived signaling pathways:a unifying hypothesis of type 2 diabetes[J].Endocr Rev,2002,23(5):599-622.
3Barroso L C,Herrera N D,Hueros J C,et al.Incidence of cardiovascular disease and validity of equations of coronary risk in diabetic patients with metabolic syndrome[J].Med Clin (Barc),2007,128(14):529-535.
4UK prospective diabetes study(UKPDS) group.Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of comp lications in patients with type 2 diabetes(UKPDS 33)[R].Lancet,2007:352-387.
5Dai C,Stolz D B,Bastacky S I,et al.Essential role of integrin linked kinase in podocyte biology:bridging the lntegrin and slit diaphragm signaling[J].J Am Soc Nephrol,2006,17(8):2164-2175.
6UK prospective diabetes gtuely(UKPDS) group.No authors listed efficacy of atenololand cap topril in reducing risk of macrovascular and microvascular complications in type 2 diabetes(UKPDS 39)[R].BMJ,1998,317(7):713-720.
7Kim S I,Kwak J H,Zachariah M,et al.TGF activated kinase and TAK binding protein cooperate to mediate TGF212 induced MKK32p38 MAPK activation and stimulation of type I collagen[J].Am J Physiol Renal Physiol,2007,291(5):1471-1478.
8Huang C C,Jinn Y G,Shyi J S,et al.Insulin and heparin suppress superoxide production in diabetic ratglomeruli stimulated with lowden sity lipoprotein[J].Kidney Int,2001,59 (1):124-130.
9Tonelli M,Moye L,Sacks F M,et al.Effect of pravastain on loss of renal function in people with moderate chronicrenal insuffciency and cardiovascular disease[J].J Am Soc Nephrol,2003,14(4):1605-1613.
10Ritz E,Ogata H,Orth S R.Smoking:a factor p romoting onset and progression of diabetic nephropathy[J].Diabe-tes Metab,2000,26(14):54-63.