摘要
目的对中药联合髓芯减压植骨术治疗Ficat I、Ⅱ期股骨头坏死的有效性做出客观评估。方法计算机检索中国生物医学文献数据库、万方数据资源系统、中国学术期刊全文数据库、中国知网、中文科技期刊数据库、Pub Med、EMBase,纳入符合标准的随机对照试验(RCT),并采用Rev Man 5.2软件进行Meta分析。结果共7篇文献464例患者符合纳入标准,未发现双盲试验。根据意向治疗分析显示与髓芯减压植骨术治疗相比,结合中药治疗早期股骨头坏死对总有效率的影响差异有统计学意义,P<0.01,优势比为3.76(2.20,6.44)。结论以本项Meta分析为基础,中药联合髓芯减压植骨术治疗早期股骨头坏死较单纯髓芯减压植骨术治疗有益,但受纳入文献质量限制,以上结论尚需要高质量的临床试验进一步证实。
Objective To make an impersonal evaluation on the effect of Chinese medicine combined with intramedullary decompression bone graft in the treatment of early femoral head necrosis. Methods Retrieving from CBD,Wanfang database,CSJD,NKI,CNKI,PubMed,EMBase and related journals literatures meet inclusion criteria were collected. Meta-analysis was performed by RevMan 5. 2 software.Results 7 RCTs,including 464 patients,met the inclusion criteria. All of the trials were not adequate in methodological quality. None of them was double-blinded trial. Comparing with intramedullary decompression bone graft,the result of analysis（ intention-to-treat,ITT）showed that therapy of integrated medicine could raise total clinical effective rate,and the difference had statistical significance（ P 〈0. 01,OR3. 76（ 2. 20,6. 44））. Conclusion The present meta-analysis suggested that therapy of integrated medicine is beneficial over intramedullary decompression bone graft in the treatment of early femoral head necrosis. But limited by the quality of included studies,the above conclusions still need high-quality clinical trials for further confirmation.
出处
《光明中医》
2017年第4期605-609,共5页
GUANGMING JOURNAL OF CHINESE MEDICINE
基金
广西科学研究与技术开发计划项目(No.1355005-6-3)
广西壮族自治区卫生厅科研课题(No.Z2013191)
关键词
中药
髓芯减压植骨术
早期股骨头坏死
随机对照试验
META分析
Chinese herbal medicine
Intramedullary decompression bone graft
Early femoral head necrosis
Randomized controlled trials
Meta-analysis
