摘要
目的:本研究旨在观察与分析参附注射液对于乳腺癌化疗患者骨髓抑制及消化道症状的临床疗效。方法:将本院乳腺外科2014年6月—2016年1月住院治疗的180例乳腺癌患者随机分为对照组和治疗组100例。其中,对照组80例,给予常规化疗;治疗组100例,给予常规化疗联合参附注射液静脉滴注。在治疗2个周期后评价两组患者的骨髓抑制及消化道症状的情况。结果:治疗组的骨髓抑制的表现,包括白细胞、中性粒细胞、红细胞以及血小板低下的发生率均低于对照组,而且均未出现Ⅳ度降低的病例,有显著性差异(P<0.05)。治疗组消化道反应包括呕吐、腹泻的发生率低于对照组,有显著性差异(P<0.05)。两组患者的便秘和口腔炎毒性分级均较低,无统计学意义(P>0.05)。结论:在对乳腺癌患者进行化疗的同时应用参附注射液,能有效抑制患者的骨髓抑制反应和消化道症状,增强患者的免疫功能,在增加患者治疗的依从性的同时,改善患者生活质量。
Objective ： This study was designed to observe and analyze the clinical efficacy of Shenfu Injection for bone marrow suppression and gastrointestinal symptoms in breast cancer patients who underwent chemotherapy. Methods ： A total of 180 breast cancer patients who underwent chemotherapy in the department of breast surgery of our hospital from June 2014 to January 2016 were recruited in this study. They were randomly divided into control group （n = 80） and treatment group （n = 100）. The patients in control group were given standard chemotherapy. The patients in treatment group were given standard chemotherapy combined with Shenfu Injection by intravenous drip. And then we evaluated the bone marrow suppression and gastrointestinal symptoms after 2 cycles of treatment. Results：The incidence of bone marrow suppression manifestations including low white blood ceils, neutro- phils, red blood cells and platelets were lower than that of the control group, and there was no case with IV degree. The differences were significant （P 〈 0. 05 ）. In addition, the incidence of gastrointestinal reactions including vomiting and diarrhea was lower than the control group. The differences were significant （ P 〈 0. 05 ）. There was no statistical significance regarding constipation and stomatitis toxicity due to low grading （P 〉 0. 05 ）. Conclusion：The application of Shenfu Injection with chemotherapy at the same time for patients with breast cancer can effectively inhibit bone marrow suppression reaction and gastrointestinal symptoms, en- hance the immunological function and the treatment adherence and improve patient quality of life.
出处
《辽宁中医杂志》
CAS
北大核心
2017年第2期315-317,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
四川省科技厅与泸州市政府
泸州医学院联合课题(201414JC0197-LH38)
关键词
参附注射液
乳腺癌
TAC
骨髓抑制
消化道症状
Shenfu Injection
breast cancer
TAC
bone marrow suppression
digestive tract symptoms
