摘要
目的 探讨替加环素对老年慢性阻塞性肺疾病（chronic obstructive pulmonary disease,COPD）合并院内感染患者血清降钙素原（procalcitonin,PCT）水平的影响及临床疗效。方法 选取COPD并院内感染老年患者82例,按随机数字表法分为对照组和研究组,分别为41例,对照组在常规治疗基础上予以头孢哌酮舒巴坦治疗,研究组在常规治疗基础上予以替加环素治疗,2组共治疗2周为一疗程,于治疗前和治疗2周后抽取肘部静脉血测定血清炎症因子及实验室相关指标,同时对比临床疗效及细菌清除状况。结果 相对于对照组,研究组治疗后血清超敏C反应蛋白（high-sensitivity C-reactive protein,hs-CRP）、白介素6（interluekin 6,IL-6）、肿瘤坏死因子α（tumor necrosis factorα,TNF-α）含量较低,血清PCT、一氧化氮（NO）含量较低,差异有统计学意义（P〈0.05）;研究组总有效率90.24%显著高于对照组总有效率70.73%与数据对比,差异有统计学意义（P〈0.05）;研究组细菌总清除率87.80%显著高于对照组总细菌清除率63.42%,差异有统计学意义（P〈0.05）。结论 替加环素治疗老年COPD并院内感染患者疗效显著,显著降低血清PCT、NO及炎症因子指标,安全性高。
Objective To investigate the effect of tigecycline on serum procalcitonin and its efficacy in the treatment of elderly chronic obstructive pulmonary disease （COPD） and nosocomial infection. Methods 82 elderly patients with COPD with nosocomial infection were selected and randomly divided into two groups with 41 cases of each group, the control group received routine treatment combined with cefoperazone and sulbactam, and the experimental group received routine treatment combined with tigecycline, 2 weeks for a course o f treatment. The serum inflammatory factors and laboratory related indexes, clinical efficacy and bacterial clearance were compared after the treatment. Results Compared with control group, the levels of serum high-sensitivity C-reactive protein （hs-CRP）, interluekin 6（IL-6） and tumor necrosis factora（TNF-a） were significantly lower, and the serum levels of PCT and NO were lower（P 〈 0.05）. The total efficacy o f experimental group was 90.24%, which washigher than 70.73% in control group （^〈0.05）. The bacterial clearance rate in the control group was 63.42%, which was lower than the experimental group of 87.80% （P 〈 0.05）. Conclusion Tigecycline in the treatment o f COPD and nosocomial infection in elderly patients is curative effective and it can reduce the serum levels of PCT, NO and inflammatory factors with high safety.
出处
《中国生化药物杂志》
CAS
2017年第1期207-209,213,共4页
Chinese Journal of Biochemical Pharmaceutics
