摘要
目的探讨抗癌平丸对结直肠癌术后FOLFOX方案化疗患者的临床疗效。方法选取2014年2月～2015年1月温岭市第一人民医院外科中心收治的78例结直肠癌术后患者,按照抽签法分为观察组和对照组2组,每组39例。对照组采取FOLFOX4方案进行治疗,观察组患者在对照组治疗基础上给予抗癌平丸进行治疗,比较2组患者治疗前后免疫功能改善情况、临床疗效、生活质量改善情况及不良反应发生情况。结果治疗后,观察组总有效率显著高于对照组,差异具有统计学意义（P〈0.05）;观察组生活质量总有效率显著高于对照组,差异具有统计学意义（P〈0.05）;2组患者口腔黏膜炎、血小板减少、血红蛋白减少、白细胞降低、周围神经毒性不良反应率比较差异无统计学意义,观察组腹泻、恶心呕吐率明显低于对照组（P〈0.05）。结论抗癌平丸对结直肠癌术后FOLFOX方案化疗患者效果显著,能有效改善患者临床症状及生活质量,增强患者免疫功能,临床疗效良好,安全性高。
Objective To study the clinical effect of Kangaiping Wan on postoperative patients with colorectal cancer treated by FOLFOX chemotherapy.Methods 78 cases of colorectal cancer patients admitted from February 2014 to January 2015 in our hospital were selected and divided into observation group and control group according,39 cases in each group.The control group was treated with FOLFOX4 regimen,and the patients in the observation group were treated with Kangaiping Wan on the basis of the control group.Two groups of patients before and after treatment of immune function improvement were compared,two groups of patients with clinical efficacy,quality of life to improve the situation,adverse reactions were compared.Results After treatment,the total effective rate of the observation group was significantly higher than the control group,the difference was statistically significant（P〈0.05）,quality of life of the observation group was significantly higher than the control group,the difference was statistically significant（P〈0.05）;There were no significant differences in the rates of oral mucositis,thrombocytopenia,hemoglobin,leukocytopenia and peripheral neurotoxicity in the two groups.The diarrhea and nausea and vomiting rate in the observation group were significantly lower than those in the control group（P〈0.05）.Conclusion FOLFOX regimen for patients with colorectal cancer after chemotherapy,combined with Kangaiping Wan,can effectively improve the clinical symptoms and quality of life of patients and enhance the immune function,the clinical efficacy is good and the safety is high.
出处
《中国生化药物杂志》
CAS
2017年第2期93-96,共4页
Chinese Journal of Biochemical Pharmaceutics
