摘要
目的探讨多糖铁复合物与叶酸联合应用对妊娠贫血患者的临床疗效及新生儿结局的影响。方法选取2013年6月～2015年8月天津市西青医院妇产科收治的82例妊娠缺铁性贫血妇女,随机分成对照组和研究组,每组41例。治疗前2 w停用有关补充铁药物,对照组予复方硫酸亚铁叶酸片（4片/次,1天3次）饭后口服,研究组予多糖铁复合物胶囊（0.15 g～0.30 g/次,1天1次）以及叶酸片（0.4 mg/次,1天1次）口服。检测2组患者治疗前后血常规以及血清Hb、SF、SI水平,并观察妊娠分娩情况以及对新生儿进行有关评价,比较治疗效果和安全性。结果与治疗前比较,2组RBC、HCT以及Ret均升高（P〈0.05）,Hb、SF以及SI水平升高（P〈0.05）;与对照组比较,研究组RBC、HCT以及Ret均较高（P〈0.05）,Hb、SF以及SI水平较高（P〈0.05）。分娩结局中,与对照组比较,研究组剖宫产率、产后出血率以及新生儿窘迫率均较低（P〈0.05）;研究组新生儿肌张力、脉搏、皱眉、肤色、呼吸评分较对照组高（P〈0.05）,体质量较对照组重（P〈0.05）;研究组患者治疗总有效率及安全性均较对照组高（P〈0.05）。结论多糖铁复合物联合叶酸对妊娠缺铁性贫血疗效确切,能明显改善新生儿机体状况。
Objective To investigate the clinical efficacy of polysaccharide iron combined with folic acid in treatment of anemia in gestation women and its effect on neonatal outcomes.Methods 82 cases of pregnant women with iron deficiency anemia were selected and randomly divided into two groups,each had 41 cases.All patients received discontinuation of iron supplementation two weeks pre-treatment,control group received compound ferrous sulfate and folic Acid Tablets（4 tablets,tid）,the treatment group received with Iron Polysaccharide Complex Capsules（0.15 g^0.30 g,qd）and Folic Acid Tablets（0.4 m,qd）.Levels of serum Hb,SF and SI between two groups were compared,and the pregnancy outcomes,neonatal outcomes,and effect and safety were observed.Results Compared with pre-treatment,levels of RBC,HCT and Ret,levels of Hb,SF and SI in two groups were all increased（P〈0.05）,and those indexes in treatment group were higher than control group（P〈0.05）.Compared with control group,birth outcomes in cesarean section,the rate of postpartum hemorrhage and neonatal distress rate in treatment group were lower（P〈0.05）,scores of neonatal muscle tension,pulse,respiration,skin frowning were higher（P〈0.05）,the total efficiency and safety were higher（P〈0.05）.Conclusion Polysaccharide iron combined with folic acid in treatment of anemia in gestation women was accurate,it can significantly improve the neonatal outcomes.
出处
《中国生化药物杂志》
CAS
2017年第2期146-148,152,共4页
Chinese Journal of Biochemical Pharmaceutics
关键词
妊娠贫血
多糖铁复合物
叶酸
新生儿结局
pregnancy anemia
polysaccharide iron
folic acid
neonatal outcomes
