摘要
目的:探讨补肾地黄丸联合多奈哌齐治疗血管性痴呆的临床疗效。方法:选择113例血管性痴呆患者,两组均进行常规对症治疗。对照组采用多奈哌齐治疗,治疗组在对照组的基础上联合补肾地黄丸治疗。评价两组临床疗效、日常生活能力量表(ADL)、健康调查简表(SF-36)及不良反应发生情况。结果:观察组有效率为87.72%明显优于对照组76.79%。治疗后两组ADL评分与治疗前比较均显著升高,且观察组ADL评分明显优于对照组(t=-3.096,P=0.003)。两组SF-36评分与治疗前比较均显著升高,且观察组SF-36评分79.20±12.37显著高于对照组75.17±6.20(t=2.195,P=0.003)。观察组不良反应率为10.53%,对照组不良反应率为21.43%(χ~2=7.472,P=0.037)。结论:补肾地黄丸联合多奈哌齐治疗血管性痴呆临床疗效显著,患者生活能力得以改善,生活质量提高,且不良反应较少。
Objective ：This study aims to investigate the clinical efficacy of Bushen Dihuang pill combined with donepezil in the treatment of vascular dementia .Methods ：113 patients with vascular dementia of the two groups were given routine symptomatic treatment .The control group was treated by donepezil ,the treatment group was treated by Bushen Dihuang pill on the basis of the control group .It evaluated the clinical efficacy ,the score of daily living scale （ADL ） and the MOS item short from health survey （SF-36） ,and also the adverse reaction of the two groups .Results ：The effective rate of the observation group was 87 .72% ,which was significantly better than that of 76 .79% in the control group .After treatment ,the ADL score of the two groups were statistically significantly higher than before treatment ,and ADL score of the observation group was statistically significantly better than that of in the control group （t= -3 .096 , P = 0 .003） .The SF-36 score of the two groups were statistically significantly higher than that of before treatment ,and SF-36 score of 79 .20 ± 12 .37 in the observation group was statistically sig-nificantly higher than that of 75 .17 ± 6 .20 in the control group （t = 2 .195 , P= 0 .003） .The adverse reaction rate was 10 .53% in the observation group ,which was lower than that of 21 .43% in the control group （χ^2 = 7 .472 ,P=0 .037） .Conclusion ：It has a significant clinical efficacy of the Bushen Dihuang pill combined with donepezil in the treatment of vascular dementia patients .It can significant improve the ability of daily living and the quality of life .It also has fewer side effects with high safety and low adverse reaction .
出处
《陕西中医》
2017年第3期328-330,共3页
Shaanxi Journal of Traditional Chinese Medicine
关键词
痴呆
血管性/中西医结合疗法
@补肾地黄丸
多奈哌齐
Dementia
vascular/integrated Chinese traditional and western medicine therapy @ Bushen Dihuang pill Donepezil
