摘要
目的探讨小脑-大脑皮层通路的白质连接模式。方法于2015年10月-2016年4月通过电子科技大学校园网公开招募20名健康被试并采集所有被试的弥散磁共振(dMRI)数据,通过概率性示踪法重建出小脑-大脑皮层之间的白质纤维束通路,包括齿状核-红核-丘脑-皮层(DTC)、额叶-脑桥-小脑(FPC)、顶叶-脑桥-小脑(PPC)、颞叶-脑桥-小脑(TPC)和枕叶-脑桥-小脑(OPC)。考察这些通路白质微结构的弥散参数,包括各向异性分数(FA)、平均扩散度(MD)、横向扩散度(AD)和径向扩散度(RD)。利用配对t检验考察各个纤维束弥散参数的对称性。结果在20名被试中均成功追踪出5组白质纤维束。DTC和OPC的各个参数均显示为双侧对称;TPC和PPC的FA存在不对称性,左侧高于右侧,差异有统计学意义(P<0.05);左侧FPC和右侧PPC的RD值较对侧高,差异均有统计学意义(P<0.05)。结论弥散磁共振数据能有效重构小脑-大脑间的白质纤维束,作为小脑输出纤维(DTC)的弥散参数具有双侧对称性。而额叶、顶叶、颞叶向小脑的输入纤维均显示双侧不对称性,这可能反映了小脑参与大脑非运动功能的不对称性。
Objective To investigate the white - matter connectivity pattern of the cerebello - cerebral white matter pathway. Methods The diffusion magnetic resonance imaging （ dMRI） data of 20 healthy adults who were recruited from University of Electronic Science and Technology of China from October 2015 to April 2016 were collected. Then, the white matter pathways between the cerebral cortex and the cerebellum were tracked by probabilistic tracing method, including dentate nucleus - rednucleus - thalamus - cortical （DTC ）,frontal - pontine - cerebellar （ FPC ） , parietal - pontine - cerebellar （ PPC ） , temporallobe - pontine - cerebellum （ TPC ）, occipital - pontine - cerebellum （OPC）. The diffusional features： Fractional Anisotropy （FA）, Mean Diffusivities （MD）, A xial Diffusivities （AD） and Radial Diffusivities （ RD） were assessed on these fibers. Finally, the symmetry of parameters of fibers was investigated by pairwise t test. Results All of fibers were successfully t r a c k e d in 20 subjects. The diffusional features of DTC and OPC were symmetric. The FA of TPC and PPC was asymmetric, in which the left fiber was higher than the right one （P 〈0. 05） . The RD of left FPC and right PPC was higher than contralateral ones （P 〈 0. 0 5 ） . Conclusion As the output fibers of the cerebellum , DTC were symmetrical. However, the asymmetric of the input fibers from frontal, temporal, parietal lobes would implicate that the the cerebellum participate in the cerebral non - motor function asymmetrically.
出处
《四川精神卫生》
2017年第1期37-40,共4页
Sichuan Mental Health
基金
国家自然科学基金(81271547)
国家重大科学仪器设备开发专项项目(2013YQ490859)
关键词
弥散磁共振
概率性示踪
小脑白质
弥散参数
Diffusion magnetic resonance
Probabilistic tracing
Cerebellar white matter
Diffusion parameter
