摘要
目的观察单用依达拉奉与联用通腑醒神汤对急性脑出血术后血清因子的影响和神经功能的恢复作用。方法采用随机数字表法将108例急性脑出血术后患者分为对照组、依达拉奉组、和联合用药组,各36例,进行对照研究。对照组给予常规治疗,其余2组在常规治疗基础上给予相应药物。各组疗程均为28 d。记录3组治疗前后14、28 d格拉斯哥昏迷量表(Glasgow coma scale,GCS)评分、临床疗效、神经功能缺损程度评分及其Barthel指数评分、检测治疗前后血清IL-6、TNF-α、MMP-9水平。结果经Kruskal-Walli H检验分析,3组中联合用药组的临床疗效最优。联合用药组的GCS评分和Barthel评分最高,神经功能损伤(NIHSS)评分最低,且TNF-α和MMP-9水平均低于对照组和依达拉奉组(P<0.05)。依达拉奉组的疗效优于对照组(P<0.05)。治疗期间3组患者均未见明显不良反应。结论依达拉奉注射液联用通腑醒神汤更有利于急性脑出血术后血清因子的降低和神经功能的恢复,减轻脑水肿,提高患者的生存质量,改善预后。
Objective To observe the influence of edaravone injection combined with Tongfuxingshen decoction on the postoperative serum factors and neurological fiinction for the patients with acute intracerebralhemorrhage. Methods 108 cases postoperative patients with acute intracerebral hemorrhage were randomly divided into control group, edaravone group and drug combination group （ 36 cases of each group）. Patients in the control group were treated with routine therapy. Patients in other two groups were treated with relevant drugs based on the routine therapy for 28 days. Primary outcomes were measured with Glasgow coma scale （GCS） index, efficacy, NIHSS index and Barthel index before and after treatment. Results The results of Kruskal- Walli H analysis showed the clinical effect of combination group was better than other groups. The GCS score and Barthel score of combination group were higher than other groups, and the NIHSS score was the lowest. The TNF-a and MMP-9 levels of combination group were lower than control group and edaravone group {P 〈 0.05）. The clinical effect in edaravone group was better than control group {P 〈 0.05）. There was no adverse reaction occurred during treatment in any group. Conclusion Edaravone injection combined with Tongfuxingshen decoction contribute to relieve intracerebral damage and intracerebral edema,and promote the prognoses in patients with acute cerebral hemorrhage after mini-invasive surgery.
出处
《中国药物警戒》
2017年第2期78-81,共4页
Chinese Journal of Pharmacovigilance
关键词
依达拉奉
通腑醒神汤
急性脑出血
血清因子
神经功能损伤
edaravone
Tongfiixingshen decoction
acute intracerebral hemorrhage
serum factor
nearological function damage
