摘要
目的探讨急性等容血液稀释(ANH)对异位妊娠手术患者T淋巴细胞亚群及NK细胞的影响。方法将96例异位妊娠手术患者分为血液稀释组(n=50)和库血输注组(n=46)。血液稀释组在术前进行ANH,库血输注组术前不进行ANH,按照输血指南适当输入库存血。测定术前、术后第3天、术后第10天T细胞亚群与NK细胞含量。记录血液稀释组血液采集和回输过程中不良反应发生情况,以及两组临床康复情况。结果血液稀释组术后第3天、术后第10天CD3^+、CD4^+、CD8^+及NK细胞含量与术前比较无显著变化(P>0.05)。库血输注组术后第3天、第10天与术前比较,CD3^+、CD4^+、NK细胞含量明显下降(P<0.05),CD8^+明显上升(P<0.05);血液稀释组术后第3天、第10天CD3^+、CD4^+、CD8^+、NK细胞含量与库血输注组比较,差异有统计学意义(P<0.05)。血液稀释组自体血采集及回输过程中均未发生严重不良反应,术后肠道排气时间、切口拆线时间及住院时间均明显短于库血输注组(P<0.05)。结论 ANH对异位妊娠手术患者T淋巴细胞亚群及NK细胞的影响较小,有助于患者术后康复。
Objective To explore the influence of acute normovolemic hemodilution（ANH）on T lymphocyte subsets and NK cells in patients with ectopic pregnancy with surgical management. Methods 96 cases of patients with ectopic pregnancy with surgical treatment were divided into hemodilution group（n=50） and banked blood infusion group（n=46）. The patients in hemodilution group were received ANH before the operation; the patients in banked blood infusion group did not received ANH before the operation and banked blood were infused according to the blood transfusion guide. The contents of T lymphocyte subsets and NK cells were detected at preoperative,postoperative 3 d and 10 d. The adverse reactions in the process of autologous blood collection and transfusion were recorded in hemodilution group. The situations of postoperative recovery were investigated in two groups. Results（1） The T lymphocyte subsets and NK cells in hemodilution group had no significant changes after operation（P〈0.05）. CD3^＋,CD4^＋,and NK cells at postoperative 3 d and 10 d were significantly decreased（P〈0.05）; CD8^＋ increased significantly（P〈0.05） in banked blood infusion group. CD3^＋,CD4^＋,CD8^＋ and NK cells at postoperative3 d and 10 d of the hemodilution group were significantly different from those of the banked blood infusion group（P〈0.05）.（2） No serious adverse reactions happened among the process of autologous blood collection and transfusion in hemodilution group; the intestinal exhaust time,take out stitches incision time and hospital stay of the hemodilution group were less than those of the banked blood infusion group（P〈0.05）. Conclusion ANH could reduce the changes in T lymphocyte subsets and NK cells in patient with ectopic pregnancy after surgical management,and was conducive to the postoperative recovery.
出处
《热带医学杂志》
CAS
2017年第1期81-84,共4页
Journal of Tropical Medicine
