摘要
在没有预置导向官能团条件下而直接进行碳氢键的化学转化,被认为是合成化学中的＂圣杯＂,一直以来受到广大合成化学家的极大关注。近年来该研究领域发展迅速,一些新反应相继被报道。但是该研究领域仍然面临诸多挑战,比如反应的选择性问题,包括区域选择性和对映体选择性等,特别是对后者的控制尤为困难,是当前有机合成化学领域中最具挑战性的难题。
C - H bond functionalization refers to transformations that introduce functional group directly via the cleavage of C- H bond, which shows excellent step- and atom-economy. A recent breakthrough was achieved by the Guosheng Liu group in collaboration with Shannon S. Stahl group from University of Wisconsin-Madison. They discovered a new strategy to achieve Cu-catalyzed enantioselective cyanation of benzylic C-H bonds via a ＂Radical Relay Process＂. The present copper-catalyzed method provides a remarkably chemo-, regio- and enantioselectivity to afford optical organonitriles efficiently under mild reaction conditions.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2017年第1期13-14,共2页
Progress in Chemistry
