摘要
口蹄疫是由口蹄疫病毒引起偶蹄动物发生的一种急性、烈性传染病,给发病地区的畜牧业造成巨大的损失,目前应用疫苗来防控口蹄疫仍是最主要的手段。作为一种新型疫苗,表位疫苗是用病毒相关抗原表位制备,可同时携带多个抗原表位及辅助性表位的疫苗,具有安全性好、易操作和可控等优势,受到人们密切的关注。近些年来,对于口蹄疫表位及疫苗的研究取得了很大的进展,现对口蹄疫病毒相关的细胞表位及其以此为基础的表位疫苗的最新进展进行综述,为研制更加安全有效的口蹄疫疫苗提供参考。
Foot and mouth disease（FMD）is caused by foot-and-mouth disease virus（FMDV）and affects cloven hoofed animals,it is an acute and potent infectious disease which has caused great loss in some regions.Up to now,people still use vaccines to prevent and control FMD which has become the the popular ways.Prepared by virus＇ antigen epitopes and carried with multiple epitopes and helper epitope,the epitope-based vaccine against FMD which has caught people＇s attention to it owing to it has high safety and is easy to be manipulated and controlled.In recent years,the research based on epitope of FMDV has made great progress.Now we review the latest progress of the FMDV epitopes and the epitope-based vaccine against FMD in this paper,in order to provide relevant preferences for the development of the vaccines with high security and efficiency.
出处
《中国畜牧兽医》
CAS
北大核心
2017年第2期396-401,共6页
China Animal Husbandry & Veterinary Medicine
基金
国家生猪产业体系项目(CARS-36-06B)
关键词
口蹄疫
CTL表位
表位疫苗
FMD
cytotoxic T cell epitope
epitope-based vaccine
