摘要
目的探讨环氧化酶-2(COX-2)、前列腺素E_2(PGE2)在结直肠癌中的表达及其与结直肠癌临床特征的关系。方法选取2009年8月1日-2012年8月1日于河北北方学院附属医院经病理检查确诊为结直肠癌78例患者的组织标本。免疫组化染色检测COX-2和PGE2的表达,并分析其与患者临床病理学特征的关系。结果结直肠癌组织中COX-2阳性表达率显著增加,与肿瘤大小、分化程度、浸润深度、淋巴结转移和Dukes分期相关;结直肠癌组织中PGE2阳性表达率显著增加,与肿瘤的分化程度、浸润深度、淋巴结转移和Dukes分期相关。Pearson相关分析表明,COX-2与PGE2在结直肠癌组织中的阳性表达显著正相关。结论COX-2、PGE2与结直肠癌的浸润、侵袭和转移密切相关。
Objective To investigate the expressions of Cyclooxygenase-2（COX-2） and Prostaglandin E2（PGE2） in colorectal carcinoma and the clinical significance. Methods Tissue specimens of 78 patients with colorectal carcinoma admitted from Aug. 1,2009 to Aug. 1,2012 in the First Affiliated Hospital of Hebei North University were enrolled in the study. The expressions of COX-2 and PGE2 were measured by immunohistochemical staining and the clinical relevance of expressions of COX-2 and PGE_2 with clinical pathological features of colorectal carcinoma were analyzed according to patients＇ medical records. Results The expression of COX-2 in colorectal carcinoma was significantly increased and related with tumor size,differentiation,depth of invasion,lymph node metastasis and Dukes classification. The expression of PGE2 in colorectal carcinoma was significantly increased and related with tumor differentiation,depth of invasion,lymph node metastasis and Dukes classification. Pearson correlation analysis indicated that the expression of COX-2 in colorectal carcinoma had a positive correlation with PGE2. Conclusion The expressions of COX-2 and PGE2 may accelerate infiltration,invasion and metastasis of colorectal carcinoma.
出处
《胃肠病学和肝病学杂志》
CAS
2017年第2期142-145,共4页
Chinese Journal of Gastroenterology and Hepatology
关键词
环氧化酶-2
前列腺素E2
结直肠癌
临床意义
Cyclooxygenase-2
Prostaglandin E2
Colorectal carcinoma
Clinical significance
