摘要
目的探讨奥曲肽与乌司他丁联合治疗急性胰腺炎(AP)的临床疗效。方法 AP患者76例,按照随机数字表法分为对照组和观察组,每组各38例。对照组采用奥曲肽治疗,观察组采用奥曲肽联合乌司他丁治疗,对比两组患者临床疗效,检测两组治疗前、治疗后3、7 d血清淀粉酶水平。结果观察组治疗后总有效率为92.11%优于对照组的60.53%,差异有统计学意义(P<0.05)。观察组与对照组血清淀粉酶差异有统计学意义(F_(分组)=164.746,P=0.000),不同时间点的血清淀粉酶差异也有统计学意义(F_(时间)=284.258,P=0.000)。两组血淀粉酶水平治疗后呈下降趋势,治疗后3、7 d观察组血清淀粉酶水平均低于对照组(P<0.05)。观察组治疗后3、7 d较治疗前下降的幅度均大于对照组(F_(交互)=84.632,P=0.000);观察组与对照组血清TNFα、IL-6、IL-8水平差异有统计学意义(F_(分组)=182.172,P=0.000),不同时间点的血清TNFα、IL-6、IL-8水平差异也有统计学意义(F_(时间)=291.381,P=0.000),两组血清TNFα、IL-6、IL-8水平治疗后呈下降趋势,治疗后3、7 d观察组血清TNFα、IL-6、IL-8水平均低于对照组(P<0.05)。观察组治疗后3、7 d较治疗前下降的幅度均大于对照组(F_(交互)=102.271,P=0.000)。结论奥曲肽与乌司他丁联合治疗AP疗效较好,能有效改善患者血清淀粉酶水平,值得临床推广使用。
Objective To investigate the effect of octretide combined with ulinastain on patients with acute pancreatitis （AP）. Methods 76 cases of patients with AP were divided into control group and observation group randomly and equally. The control group was treated with octreotide while the observation group was treated with octreotide combined with ulinastatin. The clinical efficacy of the two groups was observed and the serum amylase level before the treatment was compared with the level 3 days and 7 days after the treatment. Results The total validity rate of the observation group after treatment was 92. 11%, which was statistically higher than that in the control group 60. 53% （P〈0. 05 ）. There was significant difference in the level of serum amylase between the two groups （Fgroup = 164. 746, P=0. 000）, and the difference also exsisted at different time （Ftime =284. 258, P=0. 000）. The serum amylase level in both of the two groups fell, and the level dropped more significantly in the observation group than that in the control group at the 3rd day and 7th day after treatment （ P〈0. 05 ）. The deference in the levels of amylase before the treatment and after treatment in the observation group was greater than those in the control group （ Finteractive = 84. 632, P= 0. 000）. Conclusion The octretide combined with ulinastain has a better effect on patients with AP by effectively improving the level of serum amylase, so it is worthy of clinical application.
出处
《锦州医科大学学报》
CAS
2017年第1期49-52,共4页
Journal of Jinzhou Medical University
关键词
急性胰腺炎
奥曲肽
乌司他丁
疗效
acute pancreatitis
octreotide
ulinastatin
curative effect
