摘要
目的探讨SSRI类抗抑郁药物联合常规脑血管病治疗方案对卒中后抑郁(PSD)的治疗效果。方法选取PSD患者88例,随机分为观察组与对照组各44例。对照组予以脑血管病常规治疗,观察组在对照组的基础上加用SSRI类抗抑郁药物帕罗西汀治疗。比较2组的临床疗效、治疗前后汉密尔顿抑郁评分(HAMD)、神经功能缺损评分(NIHSS)、认知功能评分(MMSE)以及Barthel指数(BI)。结果观察组治疗总有效率为93.18%,显著高于对照组的70.45%(P<0.05);治疗后2组的HAMD及NIHSS评分均显著低于治疗前,且观察组显著低于对照组(P<0.05);治疗后2组的MMSE评分及BI指数均显著高于治疗前,且观察组显著高于对照组(P<0.05);观察组不良反应率为6.82%,对照组无不良反应。结论 SSRI类抗抑郁药物帕罗西汀与脑血管病常规药物治疗联合应用能够改善PSD患者的抑郁状态,促进神经功能、认知功能及生活能力的康复。
Objective To explore the effect of SSRI anti depression drugs combined with conventional drugs for cerebral vascular disease on treatment of patients with post stroke depression（ PSD）. Methods A total of 88 patients with PSD were randomly divided into the observation group and the control group,44 cases in each group. The control group was treated with conventional drugs for cerebral vascular disease,while the observation group was treated with paroxetine on the basis of the control groups. Clinical effect,the Hamilton depression scale（ HAMD）,neurological deficit score（ NIHSS）,cognitive function（ MMSE） score and Barthel Index（ BI） before and after treatments were compared between two groups. Results The total effective rate of observation group was 93. 18%,which was significantly higher than 70. 45% of the control group（ P〈0. 05）. After treatment,the HAMD and the NIHSS scores were significantly lower than those before treatment in both groups,and the HAMD and the NIHSS scores in the observation group were significantly lower than those in the control group（ P〈0. 05）. After treatment,the scores of MMSE and BI were significantly higher than those before treatment in both groups,and the scores of MMSE and BI in the observation group were significantly higher than those in the control group（ P〈0. 05）. In the observation group,the incidence rate of adverse reactions was 6. 82%. There were no adverse reactions in the control group.Conclusion Paroxetine combined with conventional drugs for cerebral vascular disease can improve the depressive syndromes of patients with PSD and promote the rehabilitations of nerve function,cognitive function and ability of daily living.
出处
《实用临床医药杂志》
CAS
2017年第1期25-27,共3页
Journal of Clinical Medicine in Practice
关键词
脑卒中
抑郁
抗抑郁药物
帕罗西汀
cerebral stroke
depression
anti depression drugs
paroxetine
