摘要
目的观察并分析脾多肽联合常规治疗对反复小儿呼吸道感染的疗效及免疫功能影响。方法将128例反复呼吸道感染患儿随机分成2组各64例。对照组患者采取常规治疗。观察组在对照组的基础上使用脾多肽注射液。随访6个月,记录6个月内呼吸道感染次数。观察2组患儿在治疗前后免疫球蛋白(Ig A、Ig M、Ig G)以及T淋巴细胞(CD3+、CD4+、CD8+、CD4+/CD8+)的变化。结果观察组患儿的总有效率显著高于对照组(P<0.05)。在治疗后,观察组患儿的Ig A、Ig M、Ig G水平均显著提升(P<0.05),而对照组治疗前后无显著变化(P>0.05)。观察组患儿的CD3+、CD4+和CD4+/CD8+在治疗后显著上升,CD8+显著下降(P<0.05),而对照组的T淋巴细胞亚群在治疗前后均无显著变化(P>0.05)。结论在常规治疗的基础上,采用脾多肽治疗小儿反复呼吸道感染,能显著提升临床疗效,改善患儿的免疫功能。
Objective To observe the efficacy of lienal polypeptide injection combined with conventional therapy in treatment of children with recurrent respiratory infection and their influence on immune function. Methods A total of 128 children with recurrent respiratory infection were randomly divided into observation group and control group. Control group was given conventional therapy. On the basis of control group,observation group was given additional lienal polypeptide injection. All the children were followed up for 6 months,and the occurrence of respiratory infection was recorded. The changes of Ig A,Ig M,Ig G and CD3^＋,CD4^＋,CD8^＋,CD4^＋/CD8^＋were observed. Results The total effective rate of the observation group was significantly higher than the control group（ P〈0. 05）.After treatment,the Ig A,Ig M and Ig G levels of observation group increased significantly（ P〈0. 05）while control group had no significant change（ P〉0. 05）. The CD3^＋,CD4^＋,CD4^＋/CD8^＋ of observation group increased significantly and CD8^＋decreased significantly after treatment（ P〈0. 05）,while control group had no significant change（ P〉0. 05）. Conclusion On the basis of conventional therapy,lienal polypeptide injection can improve the therapeutic effect and enhance the immune function in children with recurrent respiratory infection.
出处
《实用临床医药杂志》
CAS
2017年第1期97-99,108,共4页
Journal of Clinical Medicine in Practice
关键词
脾多肽注射液
反复呼吸道感染
免疫功能
免疫球蛋白
T淋巴细胞群
lienal polypeptide injection
recurrent respiratory infection
immune function
immunoglobulin
T lymphocyte subsets
