摘要
目的探究美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的临床疗效。方法随机选取2014年1月至2015年12月在我院就诊的溃疡性结肠炎患者130例,随机分为观察组与对照组,每组65例。对照组采用柳氮磺吡啶治疗,观察组则采用美沙拉嗪治疗,观察两组患者的临床疗效。结果对照组患者治疗总有效率为83.08%,观察组治疗总有效率为96.92%;对照组不良反应发生率为12.31%,观察组不良反应发生率为1.54%,两组比较差异均有统计学意义(P<0.05);观察组治疗后组织学积分明显低于对照组,差异具有统计学意义(P<0.05)。结论美沙拉嗪与柳氮磺吡啶均可用于治疗溃疡性结肠炎,但美沙拉嗪的临床疗效更明显,安全性更高,有进一步临床推广的价值。
Objective To explore the curative effect of mesalazine and sulfasalazine in the treatment of ulcerative colitis.Methods From January 2014 to December 2015, 130 cases of ulcer colitis patients were randomly divided into observation group and control group, with 65 cases in each group. The control group was treated with sulfasalazine treatment, the observation group was treated with mesalazine, the curative effect of two groups was compared. Results In the control group, the total effective rate was 83.08%, while the observation group was 96.92%; in the control group, the incidence rate of adverse reaction was 12.31%, while the observation group was 1.54%, the differences were statistically significant（P〈0.05）. The histological score of the observation group was significantly lower than that of the control group, the difference was statistically significant（P〈0.05）. Conclusion Mesalazine and sulfasalazine can be used in the treatment of ulcerative colitis, but mesalazine is more safe and effective, which is worthy of clinical application.
出处
《临床医学研究与实践》
2017年第4期35-36,共2页
Clinical Research and Practice
