摘要
目的探究伊曲康唑和盐酸特比萘芬序贯法治疗甲真菌病的效果和安全性。方法 120例甲真菌病患者,随机分为观察组和对照组,各60例。对照组给予伊曲康唑进行治疗,观察组给予伊曲康唑和盐酸特比萘芬序贯疗法进行治疗。观察比较两组治疗第3个月及第6个月的疗效及不良反应。结果治疗后第3个月观察组和对照组的治疗总有效率分别为91.67%(55/60)和71.67%(43/60),治疗后第6个月观察组和对照组的治疗总有效率分别为95.00%(57/60)和76.67%(46/60),两组比较差异均具有统计学意义(P<0.05);观察组和对照组的复发率分别为6.67%(4/60)和20.00%(12/60),两组比较差异有统计学意义(P<0.05);观察组的不良反应发生情况和对照组相比,差异无统计学意义(P>0.05)。结论对甲真菌病采用伊曲康唑与特比萘芬序贯疗法进行治疗,具有明显的治疗效果,安全可靠,适合推广。
Objective To explore effect and security of sequential therapy with itraconazole and terbinafine hydrochloride in the treatment of onychomycosis. Methods A total of 120 onychomycosis patients were randomly divided into observation group and control group, with 60 cases in each group. The control group received itraconazole for treatment, and the observation group received sequential therapy with itraconazole and terbinafine hydrochloride for treatment. Observation and comparison were made on effect and adverse reactions after 3 and 6 months of treatment in two groups. Results The observation group and control group had treatment effective rate after 3 months of treatment respectively as 91.67%（55/60） and 71.67%（43/60）. The observation group and control group had treatment total effective rate after 6 months of treatment respectively as 95.00%（57/60） and 76.67%（46/60）. Their differences all had statistical significance（P〈0.05）. The observation group and control group had recurrence rate respectively as 6.67%（4/60） and 20.00%（12/60）, and the difference had statistical significance（P〈0.05）. There was no statistically significant difference in incidence of adverse reactions between two groups（P〉0.05）. Conclusion Sequential therapy with itraconazole and terbinafine hydrochloride shows obviously treatment effect in the treatment of onychomycosis, and it is also safe and reliable. So it is suitable for promotion.
出处
《中国实用医药》
2017年第1期105-107,共3页
China Practical Medicine
基金
1%联苯苄唑乳膏联合40%尿素软膏治疗甲真菌病的双盲随机对照实验(项目编号:2016B01001)
关键词
甲真菌病
伊曲康唑
特比萘芬
序贯疗法
Onychomycosis
Itraconazole
Terbinafine
Sequential therapy
