摘要
目的探讨化疗患者PICC前后D-二聚体水平变化及影响因素分析。方法分析100例PICC置管后行化疗的恶性肿瘤患者,采用乳胶增强免疫比浊法检测置管前1周内及置管后4周内D-二聚体水平。PICC前后D-二聚体水平比较采用两相关样本Wilcoxon秩和检验,各组间比较采用两独立样本Wilcoxon秩和检验或多组独立样本Kruskal-Wallis H检验。结果 PICC前糖尿病患者D-二聚体水平1.330(0.463,1.828)μg/ml较非糖尿病患者0.530(0.290,0.965)μg/ml高(P=0.021),其他组间比较差异无统计学意义(P>0.05)。整体水平上,PICC置管后的D-二聚体水平1.010(0.593,1.568)μg/ml较置管前0.670(0.330,1.293)μg/ml上升(P<0.001)。PICC前后D-二聚体水平差值,肿瘤分期为Ⅳ期者0.400(0.055,0.750)μg/ml较Ⅱ/Ⅲ期者0.160(-0.170,0.360)μg/ml高(P=0.010);年龄≥60岁者为0.470(0.160,0.790)μg/ml较<60岁者0.110(-0.060,0.370)μg/ml高(P=0.001),其他组间比较差异无统计学意义(P>0.05)。结论PICC使化疗患者D-二聚体水平上升,其危险因素包括肿瘤分期为Ⅳ期及年龄≥60岁。
Objective To explore the effect of peripherally inserted central venous catheters（PICC） on plasma D-dimer levels in chemotherapy patients and analyze the influence factors. Methods One hundred cancer patients who received PICC and chemotherapy were included. The plasma D-dimer levels within one week before PICC and within 4 weeks after PICC were detected by Latex-enhanced immunoturbidimetric assay. The plasma D-dimer levels before and after PICC were compared by two related samples Wilcoxon rank sum test. The plasma D-dimer level differences between groups were analyzed by two independent samples Wilcoxon rank sum test or multiple sets of independent samples Kruskal-Wallis H test. Results Before PICC, the plasma D-dimer level of chemotherapy patients with diabetes was 1.330（0.463, 1.828） μg/ml, which was higher than the level of those without diabetes 0.530（0.290, 0.965） μg/ml（P=0.021）, and the differences were not statistically significant between other groups（P0.05）. On the whole, the plasma D-dimer level after PICC was 1.010（0.593, 1.568） μg/ml, which was higher than the level before PICC 0.670（0.330, 1.293） μg/ml（P0.001）. The plasma D-dimer level of concentration differences before and after PICC in clinical stage Ⅳ was 0.400（0.055, 0.750） μg/ml, which was higher than the level in clinical stage Ⅱ/Ⅲ 0.160（-0.170, 0.360） μg/ml（P=0.010）; the level in age≥60 years old was 0.470（0.160, 0.790） μg/ml, which was higher than the level in age60 years old 0.110（-0.060, 0.370） μg/ml（P=0.001）, and the differences between other groups were not statistically significant（P0.05）. Conclusion PICC could elevate the plasma D-dimer levels in chemotherapy patients, and the risk factors include tumor stage Ⅳ and age≥60 years old.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2017年第2期124-128,共5页
Cancer Research on Prevention and Treatment
基金
上海市卫生系统先进适宜技术推广项目(03.02.14.006)
