摘要
近期国家卫生计生委脑卒中防治工程委员会在全国脑卒中大会上发布了《中国血管性认知障碍诊疗指导规范》一文,现整理如下,供广大医务人员参考学习。
Objective To investigate the changes of serum ICTP levels and clinical significance in patients with coronary heart dis-ease. Methods 64 cases of patients with coronary heart disease were selected. According to different conditions,the patients were di-vided into acute myocardial infarction group （ AMI group, n= 17 ）, unstable angina pectoris group （ UAP group,n= 21 ） and stable angina pectoris group （ SAP group,n = 26）. Meanwhile,30 healthy persons were selected as control group （ C group）. The serum levels of ICTP,matrix metalloproteinase-2 （ MMP-2 ）, MMP-9,C reactive protein （ CRP ） and interleukin-6 （ IL-6 ） were compared a-mong the four groups. Additionally, the correlations between ICTP, MMP-2, MMP-9 and intravascular ultrasound detection results were analyzed as well. Results The serum levels of ICTP, MMP-2, MMP-9, IL-6 and CRP in AMI group and UAP group were signif-icantly higher than the SAP group and C group （ P 〈 0.05 ）. The serum level of IL-6 in AMI group was significantly higher than the UAP group （ P 〈0.05 ）.The ratios of minimal patch area,patch burden, lipid and necrosis in SAP group were significantly lower than the UAP group AMI group （ P 〈0.05） while the fibrous composition of plaque was significantly higher than the UAP group ： AMI group （ P 〈 0.05 ）. There was positive correlation between ICTP and the fibrous composition of plaque,lipid ratio, MMP-9 and MMP-2 （ P 〈 0.05 ）. Conclusions The serum levels of CTP in patients with coronary heart disease were significantly increasedMwhich can be used to evaluate the instability of atherosclerotic plaque .
出处
《心脑血管病防治》
2017年第1期3-6,96,共4页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
