摘要
目的：探讨血清降钙素原（PCT）在全身细菌性感染早期诊断中的临床价值。方法选取57例表现疑为细菌感染患者作为观察组，同期选择57例体检正常者作为对照组，根据 ACCP／SCCM共识会议及临床相关表现将观察组57例患者分为脓毒血症组（A 组）、局部细菌感染组（B 组）和细菌感染性 SIRS 组（C组），每组19例，四组均行血清降钙素原测定，比较四组不同时期及观察组中三组治疗前后不同时期血清降钙素原水平。结果（1）观察组与对照组在年龄、性别、身高、体质量及体质量指数（BMI）等一般情况上差异间差异无统计学意义（P ＞0．05）；（2）在入院时，观察组中各组别 PCT 水平均明显高于对照组，且 A 组 PCT 表达水平最高，组间差异有统计学意义（F ＝94．88，P ＜0．001），在入院治疗后24 h、3 d、7 d、10 d 后，对照组 PCT水平无明显变化，差异无统计学意义（P ＞0．05），观察组 PCT 水平均逐渐降低，但 A 组 PCT 水平仍高于其他三组，组间差异有统计学意义（F ＝62．40，P ＜0．001；F ＝65．00，P ＜0.001；F ＝58．84，P ＜0．001；F ＝63．05，P ＜0．001）。结论血清 PCT 具有一定的灵敏度与特异性，可反映疾病的严重程度，且在判断疾病的发展和预后方面也有一定的临床意义，可以考虑作为临床上检测细菌感染的首选指标之一。
Objective To study the clinical value of serum procalcitonin（PCT）in early diagnosis of systemic bacterial infection.Methods 57 suspected bacterial infectious patients in our hospital were selected as observation group,and another 57 healthy subjects were selected as control group.Patients in the observation group were divided into sepsis group （A group,19 cases）,local bacterial infection group （B group,19 cases）and bacterial infectious SIRS group （C group,19 cases）according to ACCP/SCCM consensus conference and their clinical manifestations. The serum PCT levels in the 4 groups were detected and compared.Results There was no statistically significant differences in general situation （age,sex,height,weight and body mass index （BMI）,etc.）between the two groups （P 〉0.05）.After admission,the PCT level in the observation group was obviously higher than that in the control group,the level of PCT was the highest in group A,and the difference was statistically significant（F =94.88,P 〈0.001）.24h,3d,7d and 10d after admission,there was no statistically significant difference in PCT level in control group（P 〉0.05）;the PCT level in the observation group was gradually decreased,the level of PCT in A group was still higher than that in the other three groups,and the differences were statistically significant（F =62.40,P 〈0.001;F =65.00,P 〈0.001;F =58.84,P 〈0.001;F =63.05,P 〈0.001）.Conclusion Serum PCT has a certain advan-tage in sensitivity and specificity,it can reflect the severity of disease,it also has certain clinical significance in judging the development and prognosis of disease.Therefore,it can be considered as one of the first choice for clinical detection of bacterial infection.
出处
《中国基层医药》
CAS
2017年第4期593-595,共3页
Chinese Journal of Primary Medicine and Pharmacy
