摘要
目的：研究乌司他丁治疗心肺复苏后脑损伤疗效及预后影响。方法选择至急诊科就诊患者84例，随机将其分为常规治疗组（A 组）和乌司他丁辅助治疗组（B 组），每组42例，分别于心肺复苏后于复苏即刻（T0）及复苏后1 d（T1）、3 d（T2）、7 d（T3）进行格拉斯哥昏迷评分（GCS）、急性生理与慢性健康评分（APACHE-Ⅱ评分），并记录两组患者住院时间、机械通气时间、病死率、多器官功能障碍综合征（MODS）发生情况。结果心肺复苏后 T0、T1时两组 GCS 评分比较差异未见统计学意义（P ＞0.05），T2、T3时两组 GCS 评分比较差异有统计学意义（P ＜0.05）；两组复苏后1、3、7 d APACHE-Ⅱ评分均逐渐降低，T1与 T2时组内比较差异未见统计学意义（P ＞0.05），T3时 APACHE-Ⅱ评分明显低于 T1（P ＜0.05）；两组 APACHE-Ⅱ评分比较，T1、T2时两组差异未见统计学意义（P ＞0.05），T3时 B 组评分明显低于 A 组，差异有统计学意义（P ＜0.05）；两组住院时间与机械通气时间比较差异有统计学意义（P ＜0.05），B 患者病死率与 MODS 发生率均低于 A 组，差异有统计学意义（ P ＜0.05）。结论乌司他丁运用于心肺复苏后脑损伤治疗能够缩短住院时间，增加患者存活率，改善患者预后，具有较好治疗效果。
Objective To study the therapeutic effect of ulinastatin on brain injury and prognosis of cardiopulmonary resuscitation. Methods A total of 84 cases in the emergency department were randomly divided into routine treatment group（ group A）and ulinastatin treatment group（ group B）, with 42 cases in each group. The Glasgow Coma Scale（GCS）,acute physiology and chronic health score （APACHE-Ⅱ）were performed at 1 d（T1 ）,3 D（T2 ）,7 d（T3 ）,and acute physiology and chronic health score（GCS）,respectively after cardiopulmonary resuscitation（CPR）and resuscitation（T0 ）and resuscitation. The incidence of hospitalization time,mechanical ventilation time,mortality and multiple organ dysfunction syndrome（MODS）were recorded in the two groups. Results At T0 ,T1 ,the GCS had no significant difference between the two groups（ P 〉 0. 05）;at T2 ,T3 ,there was significant difference between the two groups（ P 〈0. 05）,APACHE-Ⅱ of T3 was significantly lower than that of T1（ P 〉 0. 05）,group B were significantly lower than group A at T3 ,the difference was significant（P 〈 0. 05）. The two groups had significant differences in hospitalization time and mechanical ventilation time（P 〈 0. 05）,the fatality and incidence of MODS in group B were lower than those in group A,the differences were significant（P 〈 0. 05）. Conclusions Ulinastatin in treatment of brain injury after cardiopulmonary resuscitation can shorten the hospitalization time,increase the survival rate of the patients,improve the prognosis of patients,has good treatment effect.
出处
《中国实用医刊》
2017年第3期22-24,共3页
Chinese Journal of Practical Medicine
关键词
乌司他丁
心肺复苏
脑损伤
Ulinastatin
Cardiopulmonary resuscitation
Brain injury
