摘要
目的观察滋阴消痹方治疗糖尿病周围神经病变(DPN)的临床疗效以及对患者血同型半胱氨酸(HCY)水平的影响。方法将符合纳入标准的60例患者分为对照组(30例)及观察组(30例),在有效降糖、降压、降脂的前提下,对照组予口服甲钴胺治疗,观察组予中药滋阴消痹方治疗。两组均以2个月为1个疗程。观察对比治疗前后中医证候积分、密歇根神经病变筛查表(MNSI)体格检查评分及血HCY水平变化。结果两组均能有效改善中医证候积分、MNSI体格检查评分,且组间比较提示观察组显著优于对照组,差异有统计学意义(P<0.05)。观察组总有效率优于对照组。治疗后两组血HCY水平均有降低,且观察组与对照组效果相当。结论滋阴消痹方治疗肝肾亏虚型DPN患者临床疗效明显,不仅改善患者症状、体征,还降低血HCY水平,延缓病情进展,治疗过程无明显不良反应。
Objective To observation the clinical therapeutic effect of ziyin xiaobi formula on diabetic peripheral neuropathy（ DPN） and the impact on HCY. Methods Sixty patients in compliance with the inclusive criteria were divided into a control group（ 30 cases） and an observation group（ 30 cases）. On the basis of the effective anti-hyperglycemia,anti-hypertension and anti-hyperlipdiemia,mecobalamine was prescribed for oral administration. In the observation group,ziyin xiaobi formula was used. The duration of treatment was 2 months as one session in the two groups. TCM symptom score,MNSI score and HCY were observed and compared before and after treatment. Results In both the observation group and the control group,TCM symptom score and MNSI score were effectively improved. In comparison between the groups,the results in the observation group were significantly better than those in the control group,indicating the significant difference（ P〈0. 05）. The total effective rate in the observation group was better than that in the control group. After treatment,HCY was reduced in both of the two groups,and the result in the observation group was similar to the control group. Conclusion Ziyin xiaobi formula achieves the apparent therapeutic effect on DPN differentiated as liver and kidney deficiency. It relieves symptoms and physical signs,reduces HCY and retards the progression of sickness. There is no apparent adverse reaction in the treatment.
出处
《世界中西医结合杂志》
2017年第1期122-125,共4页
World Journal of Integrated Traditional and Western Medicine
