摘要
目的探讨普拉洛芬联合氟米龙治疗重度干眼患者的临床疗效。方法以随机数字法将212例重度干眼患者随机分为2组,每组106例。对照组给予氟米龙,观察组在对照组的基础上加用普拉洛芬。治疗前后,检测患者干眼症状评分(SPEED)、角膜荧光素染色(FLS)评分、泪膜破裂时间(BUT)、泪液分泌试验(SchirmerⅠ)、炎症因子指标[白介素-6(IL-6)、白介素-10(IL-10)、肿瘤坏死因子α(TNF-α)],并统计2组的治疗效果。结果治疗后,2组SPEED评分、FLS评分均明显降低(P<0.05),且观察组SPEED评分、FLS评分明显低于对照组(P<0.05)。治疗后,2组BUT、SchirmerⅠ水平均明显升高(P<0.05),且观察组BUT、SchirmerⅠ水平明显高于对照组(P<0.05)。治疗后,2组IL-6、IL-10、TNF-α水平均明显下降(P<0.05),且观察组IL-6、IL-10、TNF-α水平明显低于对照组(P<0.05)。治疗后,观察组治疗总有效率为90.6%,显著大于对照组的77.4%(P<0.05)。治疗后,观察组不良反应总发生率为5.7%,显著低于对照组的14.2%(P<0.05)。结论普拉洛芬联合氟米龙可以有效改善重度干眼患者的症状,增强泪膜稳定性,减轻眼表损伤,治疗效果满意。
Objective To evaluate the clinical efficacy of Pranoprofen combined Flumetholon in treatment of severe dry eye. Methods Two hundred and twelve patients with severe dry eye were randomly divided into two groups by random number method with 106 cases in each group. The control group was administrated with Flumetholon, while the observation group with additional Pranoprofen based on the treatment in the control group. Before and after the treatment, the SPEED score for dry eye symptoms, fluorescein staining （FLS） score, tear film break-up time （ BUT）, Schirmer test （ Schirmer ] ）, levels of inflammatory cytokines indicators [ interleukin-6 （ IL-6 ）, interleukin-10（ IL-10 ）, tumor necrosis factor α （ TNF- α） ] of the two groups were tested, and the efficacy of the two groups were compared. Results After the treatment, SPEED score, FLS scores of both groups were significantly reduced （P 〈 0.05）, and the SPEED score, FLS scores of the observation group were significantly lower than those of the control group （ P 〈 0. 05 ）. After the treatment, BUT and Schirmer I of both groups were significantly increased （P 〈 0. 05 ）, and those of the observation group were significantly higher than those of the control group（ P 〈 0.05）. After the treatment,levels of IL-6, IL-10 and TNF-α of the two groups were significantly reduced（P 〈 0. 05 ）, and those of the observation group were significantly lower than those of the control group （P 〈 0.05 ）. After the treatment, the total effective rate of the observation group was 90.6%, which was significantly higher than that of the control group （77.4%）, P 〈 0.05. After the treatment, the incidence of adverse reactions of the ob- servation group was 5.7%, which was significantly lower than 14.2% in the control group（P 〈 0. 05 ）. Conclusion For the severe dry eye patients, Pranoprofen combined Flumetholon can effectively improve the symptoms, enhance tear film stability, and reduce the ocular surface damage, with satisfaction efficacy.
出处
《中华全科医学》
2017年第3期431-433,482,共4页
Chinese Journal of General Practice
关键词
普拉洛芬
氟米龙
重度干眼
Pranoprofen
Flumetholon
Severe dry eye
