摘要
目的采用Meta分析法探讨肝癌患者血清微量元素水平。方法系统检索建库以来2016年6月前有关肝癌与血清微量元素水平的文献资料,采用Rev Man5.2统计软件进行分析,Q检验和I2检验验证异质性大小,采用敏感性分析和亚组分析探讨异质性的来源,采用漏斗图法识别发表偏倚。结果共纳入文献14篇,肝癌组636例,对照组851例,血清铜、锌、铁水平合并标准化均数差和95%可信区间分别为(1.65,1.28~2.03)、(-1.52,-2.14^-0.91)、(-1.21,-1.79^-0.63),差异有统计学意义(Z分别为8.69、4.85、2.70,P<0.001),Mn、Mg水平在两组间差异无统计学意义(P>0.05)。结论肝癌患者存在微量元素异常,血清Cu升高,血清Zn、Fe降低,Mn、Mg表现为不平衡状态,说明肝癌与微量元素水平有关,有必要开展更广泛和深入的微量元素研究。
Objective To estimate the association between trace element levels and liver cancer by using Meta-analysis. Methods Searching and collecting Chinese and English literatures for articles on trace element levels of liver cancer including CNKI,Wanfang database and Weipu database,Medline,Database,Embase,Cochrane Library Database and Science Direct Database from the inception to / through June 2016.Statistical analysis was conducted using Rev Man 5.2. Cochrane＇s Q test and I2 statistic were used to explore the heterogeneity across studies while subgroup analysis and sensitivity analysis for the sources of heterogeneity.The possibility of publication bias was assessed by funnel plot. Results 14 eligible studies were identified which involved 636 cases of liver cancer and 851 cases in control group.The combined standardization mean difference（ SMD） and 95% confidence intervals（ 95% CI） of Cu,Zn,Fe between two groups were（ 1. 65,1. 28 ～ 2.03） 、（-1.52,-2.14 ～-0.91） 、（-1.21,-1.79 ～-0.63） respectively,and the difference was statistically significant（ Z= 8.69、4.85、2.70,P0.001）. Conclusion Our finding suggests that there was abnormality in trace elements of patients with hepatocellular carcinoma： compared to the control group,the concentration of serum Cu in liver cancer cases was increased,the concentration of serum Zn and Fe were decreased,while the concentration of serum Mn and Mg were unbalanced,indicating that the concentration of trace elements were related to the risk of liver cancer.Thus,it is necessary to carry out more extensive and in-depth studies of trace elements.
出处
《中南医学科学杂志》
CAS
2017年第1期42-47,共6页
Medical Science Journal of Central South China
基金
"公共卫生与预防医学"湖南省重点学科经费资助
"疾病控制评价中心"南华大学校级重点点实验室经费资助(NHSYS04)
湖南省教育厅科学研究重点项目资助(16A185)
湖南省高层次卫生人才"225"工程学科带头人项目基金资助
