摘要
目的:探讨CD146在儿童与成人急性B淋巴细胞白血病(B-ALL)细胞中表达的差异及其与其他抗原、临床、分子生物学及细胞遗传学特征的关系。方法:应用流式细胞仪检测CD146在儿童(44例)与成人(24例)BALL中的表达情况,并分析CD146异常高表达与性别、初诊时外周血血象、骨髓原始淋巴细胞与幼稚淋巴细胞比例等参数的关系,比较CD146与其他抗原之间的相关性,以及CD146异常高表达患者1个疗程的缓解率。结果:成人B-ALL中CD146异常高表达率为29.17%(7/24),儿童B-ALL中CD146异常高表达率为9.09%(4/44),在成人组显著高于儿童组(P<0.05);在成人组中CD146与CD64(r=0.491,P<0.05)和CD117(r=0.578,P<0.05)呈正相关关系,在儿童组中CD146与CD71(r=0.419,P<0.01)、CD58(r=0.301,P<0.05)呈正相关关系;经1个疗程的正规化疗后,异常高表达CD146的成人组和儿童组的缓解率均低(P<0.05)。结论:成人B-ALL患者的CD146表达率高于儿童B-ALL患者。CD146与预后较差的抗原呈正相关。CD146可能是一个预后不良的指标。
Objective;To explore the differences of CD146 expression in adult and children＇s acute B cell lymphoblastic leukemia（B-ALL）,and its relation with clinical features,molecular biological and cytogenetic claracteristics.Methods;The expression of CD146 in bone marrow samples from adult and children＇s B-ALL patients were detected by flow cytometry（FCM） and the relation of CD146 abnormal high expression with the patients＇ clinical features,molecular biological and cytogenetical characteristics,as well as other antigens were analyzed.Results：The abnormal high expression rates of CD146 in adult and children＇s B-ALL patients were 29.17%and 9.09%respectively,showing that the expression rate of CD 146 in adult patients was higher than that in children＇s patients（P 〈0.05）.In adult B-ALL,CD146 was positively related with CD64 and CD117,while in children＇s B-ALL CD146 was positively related with CD71 and CD58（P〈0.05）.After 1 course of standardized chemotherapy,the complete remission rates in adult and children＇s B-ALL patients with abnormal high expression of CD146 both were low as compared with adult and children＇s B-ALL without abnormal high expression of CD146（P〈 0.05）.Conclusion：The expression rate of CD146 in adult B-ALL is higher than that in children＇s B-ALL.The CD146 positively relates with poor prognostic antigens,the CD 146 may be one poor prognosis marker.
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2017年第1期30-34,共5页
Journal of Experimental Hematology
