摘要
目的探讨复方温中愈疡汤联合奥美拉唑治疗阳虚血瘀型十二指肠溃疡患者的临床效果及其安全性。方法将阳虚血瘀型十二指肠溃疡患者92例随机分为对照组和研究组,每组46例。对照组患者给予奥美拉唑治疗,研究组患者给予复方温中愈疡汤联合奥美拉唑治疗,两组患者均持续治疗5周。比较两组患者治疗前后中医症状评分、两组患者的临床疗效、幽门螺杆菌根除率、治疗半年后复发率及不良反应发生情况。结果治疗后,两组患者中医症状评分均显著降低(P<0.05);研究组患者中医症状评分显著低于对照组、治疗总有效率和幽门螺杆菌根除率高于对照组(P<0.05);研究组患者不良反应发生率显著低于对照组(P<0.05);治疗半年后研究组患者复发率显著低于对照组(P<0.05)。结论复方温中愈疡汤联合奥美拉唑治疗阳虚血瘀型十二指肠溃疡,临床疗效显著,安全性高,值得推广应用。
Objective To observe the effect and safety of compound wenzhong yuyang decoction combined with omeprazole in treatment of patients with duodenal ulcer of deficiency of yang and blood stasis. Methods A total of 92 cases with duodenal ulcer of deficiency of yang and blood stasis patients were randomly divided into control group and study group, with 46 cases in each group. The control group were given omeprazole, while the study group received compound wenzhong yuyang decoction combined with omeprazole, the two groups were treated for 5 weeks. Chinese medicine symptoms score, clinical efficacy and helicobacter pylori eradication rate were compared between the two groups, adverse reaction during treatment and recurrence after six months of the two groups were also observed. Results Compared with that before treatment, Chinese medicine symptom score in the two groups was significantly decreased after treatment （ P 〈 0.05 ） ; and the Chinese medicine symptom score in the study group was significantly lower than that of the control group （P 〈 0.05）, the eradication rate of helicohacter pylori and total effective rate in the study group were significantly higher than those of the control group （ P 〈 0.05 ） ; the incidence of adverse reactions in the study group was significantly lower than that of the control group （ P 〈 0.05 ） ; after six months of treatment, the recurrence rate of the study group was significantly lower than that of the control group （P 〈 0.05）. Conclusions Compound wenzhong yuyang decoction combined with omeprazole in treatment of duodenal ulcer of deficiency of yang and blood stasis has a significant effect, and it is safety, which is worthy of clinical application.
出处
《内科》
2017年第1期27-29,57,共4页
Internal Medicine
关键词
十二指肠溃疡
阳虚血瘀型
治疗
复方温中愈疡汤
奥美拉唑
Duodenal ulcer
Deficiency of yang and blood stasis
Treatment
Compound wenzhong yuyang decoction
Omeprazole
