摘要
目的探讨利巴韦林、阿糖腺苷、醒脑静注射液联合用于小儿手足口病治疗的可行性。方法选取本站2012年6月至2013年4月期间80例诊断为手足口病的患儿,随机分为两组各40例。对照组使用阿糖腺苷治疗,治疗组在此基础上加用利巴韦林气雾剂、醒脑静注射液。观察治疗后患儿的症状改善效果,以及治疗前后患儿的血清细胞因子水平变化。结果治疗后,治疗组患儿的症状改善有效率为95.0%,显著高于对照组的82.5%,差异有统计学意义(P<0.05)。两组治疗前的血清细胞因子水平差异无统计学意义(P>0.05),治疗后治疗组的IL-1β、IL-10及TNF-α水平均显著优于对照组(P<0.05)。结论利巴韦林、阿糖腺苷、醒脑静注射液联合用于治疗手足口病患儿具有显著的临床效果,能有效降低各血清细胞因子水平,加快患儿恢复。
Objective To explore the feasibility of combined treatment with ribavirin aerosol, Xingnaojing injection and vidarabine for children with hand-foot-mouth disease. Methods 80 cases of children with hand-foot-mouth disease in our station from June 2012 to April 2013 were selected and randomly divided into two groups, with 40 cases in each group. The control group was treated with vidarabine, while the treatment group was given combined treatment with ribavirin aerosol, Xingnaojing injection and vidarabine. The improvement of symptoms and changes of serum cytokine levels after treatment were observed. Results The effective rate of improvement of symptoms of treatment group was 95.0%, significantly higher than 82.5% of control group （P〈0.05）. Before treatment, no statistical difference was found between two groups in the levels of serum cytokines （P〉0.05）, while after treatment, the levels of IL-1β, IL-10 and TNF-α of treatment group were significantly better than those of control group （P 〈0.05）. Conclusions The combined treatment with ribavirin aerosol, Xingnaojing injection and vidarabine for children with hand-foot-mouth disease has significant efficacy, which can effectively reduce the levels of serum cytokines, and promote the recovery of children.
出处
《临床医学工程》
2017年第2期189-190,共2页
Clinical Medicine & Engineering
关键词
阿糖腺苷
醒脑静注射液
利巴韦林
手足口病
效果
Vidarabine
Xingnaojing injection
Ribavirin aerosol
Hand-foot-mouth disease
Effect
